Dietary Calcium and Serum 25-Hydroxyvitamin D Status in Relation to BMD Among US Adults

HA Bischoff-Ferrari, DP Kiel, B Dawson-Hughes, JE Orav, R Li, D Spiegelman, Thomas Dietrich, WC Willett

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187 Citations (Scopus)


A higher calcium intake is still the primary recommendation for the prevention of osteoporosis, whereas vitamin D deficiency is often not addressed. To study the relative importance of dietary calcium intake and serum 25-hydroxyvitamin D [25(OH)D] status in regard to hip BMD, 4958 community-dwelling women and 5003 men >= 20 yr of age from the U.S. NHANES III population-based survey were studied. Calcium supplement users and individuals with a prior radius or hip fracture were excluded. We calculated standardized means for BMD by quartiles of sex-specific calcium intake for three 25(OH)D categories (566 mg/d) was not significantly, associated with BMD at 25(OH)D concentrations >50 nM. Among men, there was no significant association between a higher calcium intake beyond the upper end of the lowest quartile (626 mg/d) and BMD within all 25(OH)D categories. Among both sexes, BMD increased stepwise and significantly with higher 25(OH)D concentrations (
Original languageEnglish
Pages (from-to)935-942
Number of pages8
JournalJournal of Bone and Mineral Research
Issue number5
Publication statusPublished - 1 May 2009


  • adults
  • 25-hydroxyvitamin D
  • men and women
  • dietary calcium intake
  • BMD


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