Dictyostelium: an ideal organism for genetic dissection of Ras signalling networks

JR Chubb, Robert Insall

Research output: Contribution to journalReview article

25 Citations (Scopus)


Signalling pathways based on the small GTPase Ras regulate a multitude of cellular events in eukaryotic cells;. Dictyostelium expresses a large and varied family of Ras proteins. It also uses a range of known Ras regulators, in particular RasGEFs, and effecters. The genetic tractability of Dictyostelium. together with the wide range of Ras proteins and regulators, make it an ideal model for the genetic dissection of Ras pathways. This review highlights the recent advances in our understanding of Ras function in Dictyostelium, and considers the implications of these findings for our understanding of eukaryotic signal transduction. (C) 2001 published by Elsevier Science B.V.
Original languageEnglish
Pages (from-to)262-271
Number of pages10
JournalBiochimica et Biophysica Acta (BBA) - General Subjects
Issue number3
Publication statusPublished - 1 Mar 2001


  • Dictyostelium discoideum
  • guanine nucleotide exchange factor
  • motility
  • cell
  • endocytosis
  • small GTPase
  • RasGEF


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