Diagnosis of defects in the type 1 cytokine pathway

David Lammas; Pamela Drysdale; Anne Ben-smith; John Girdlestone; D Edgar; Dinakantha Kumararatne

doi:10.1016/S1286-4579(00)01313-7

Diagnosis of defects in the type 1 cytokine pathway

David Lammas, Pamela Drysdale, Anne Ben-smith, John Girdlestone, D Edgar, Dinakantha Kumararatne

Immunology and Immunotherapy

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.

Original language	English
Pages (from-to)	1567-78
Number of pages	12
Journal	Microbes and Infection
Volume	2
Issue number	13
DOIs	https://doi.org/10.1016/S1286-4579(00)01313-7
Publication status	Published - 1 Nov 2000

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title = "Diagnosis of defects in the type 1 cytokine pathway",

abstract = "Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.",

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AU - Drysdale, Pamela

AU - Ben-smith, Anne

AU - Girdlestone, John

AU - Edgar, D

AU - Kumararatne, Dinakantha

PY - 2000/11/1

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AB - Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.

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JO - Microbes and Infection

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Diagnosis of defects in the type 1 cytokine pathway

Abstract

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