Diagnosis of defects in the type 1 cytokine pathway

David Lammas, Pamela Drysdale, Anne Ben-smith, John Girdlestone, D Edgar, Dinakantha Kumararatne

Research output: Contribution to journalArticle

12 Citations (Scopus)


Patients with inherited defects in the interleukin-12 (IL-12)-dependent, 'high-output' interferon-gamma (IFN-gamma) pathway exhibit selective susceptibility to poorly pathogenic mycobacterial and salmonella infections. This review summarises the extended clinical spectrum seen in this group of patients and indicates a strategy for the identification of putative defects in the type 1 cytokine pathway.
Original languageEnglish
Pages (from-to)1567-78
Number of pages12
JournalMicrobes and Infection
Issue number13
Publication statusPublished - 1 Nov 2000


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