Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers?

Matthew N. Hodgkin; Trevor R. Pettitt; Ashley Martin; Robert H. Michell; Anthony J. Pemberton; Michael J.O. Wakelam

doi:10.1016/S0968-0004(98)01200-6

Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers?

Matthew N. Hodgkin^*
, Trevor R. Pettitt
, Ashley Martin
, Robert H. Michell
, Anthony J. Pemberton
, Michael J.O. Wakelam

^*Corresponding author for this work

Research output: Contribution to journal › Review article › peer-review

255 Citations (Scopus)

Abstract

In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.

Original language	English
Pages (from-to)	200-204
Number of pages	5
Journal	Trends in Biochemical Sciences
Volume	23
Issue number	6
DOIs	https://doi.org/10.1016/S0968-0004(98)01200-6
Publication status	Published - 1 Jun 1998

ASJC Scopus subject areas

Biochemistry
Molecular Biology

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10.1016/S0968-0004(98)01200-6

Cite this

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title = "Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers?",

abstract = "In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.",

author = "Hodgkin, \{Matthew N.\} and Pettitt, \{Trevor R.\} and Ashley Martin and Michell, \{Robert H.\} and Pemberton, \{Anthony J.\} and Wakelam, \{Michael J.O.\}",

year = "1998",

month = jun,

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doi = "10.1016/S0968-0004(98)01200-6",

language = "English",

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journal = "Trends in Biochemical Sciences",

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number = "6",

}

TY - JOUR

T1 - Diacylglycerols and phosphatidates

T2 - Which molecular species are intracellular messengers?

AU - Hodgkin, Matthew N.

AU - Pettitt, Trevor R.

AU - Martin, Ashley

AU - Michell, Robert H.

AU - Pemberton, Anthony J.

AU - Wakelam, Michael J.O.

PY - 1998/6/1

Y1 - 1998/6/1

N2 - In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.

AB - In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.

UR - https://www.scopus.com/pages/publications/0032102323

U2 - 10.1016/S0968-0004(98)01200-6

DO - 10.1016/S0968-0004(98)01200-6

M3 - Review article

C2 - 9644971

AN - SCOPUS:0032102323

SN - 0968-0004

VL - 23

SP - 200

EP - 204

JO - Trends in Biochemical Sciences

JF - Trends in Biochemical Sciences

IS - 6

ER -

Diacylglycerols and phosphatidates: Which molecular species are intracellular messengers?

Abstract

ASJC Scopus subject areas

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