TY - JOUR
T1 - Diacylglycerols and phosphatidates
T2 - Which molecular species are intracellular messengers?
AU - Hodgkin, Matthew N.
AU - Pettitt, Trevor R.
AU - Martin, Ashley
AU - Michell, Robert H.
AU - Pemberton, Anthony J.
AU - Wakelam, Michael J.O.
PY - 1998/6/1
Y1 - 1998/6/1
N2 - In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.
AB - In eukaryotes, many receptor agonists use phospholipase-generated lipids as intracellular messengers. Receptor occupation stimulates the production of polyunsaturated 1,2-diacylglycerols by phosphatidylinositol-4,5-bisphosphate- specific phospholipases C and/or of mono-unsaturated and saturated phosphatidates by phospholipase-D-catalysed phosphatidylcholine breakdown. The primary phospholipase products are rapidly metabolized: polyunsaturated 1,2-diacylglycerols are converted to polyunsaturated phosphatidates by diacylglycerol kinase; mono-unsaturated and saturated phosphatidates are dephosphorylated to give mono-unsaturated and saturated 1,2-diacylglycerols by phosphatidate phosphohydrolase. The phospholipase-generated polyunsaturated 1,2-diacylglycerols and mono-unsaturated and saturated phosphatidates appear to be intracellular messengers, whereas their immediate metabolites probably do not have signalling functions.
UR - http://www.scopus.com/inward/record.url?scp=0032102323&partnerID=8YFLogxK
U2 - 10.1016/S0968-0004(98)01200-6
DO - 10.1016/S0968-0004(98)01200-6
M3 - Review article
C2 - 9644971
AN - SCOPUS:0032102323
SN - 0968-0004
VL - 23
SP - 200
EP - 204
JO - Trends in Biochemical Sciences
JF - Trends in Biochemical Sciences
IS - 6
ER -