Diabetologia: Albuminuria is a marker of increasing intra- and extracranial vascular involvement in Type 2 diabetic Chinese patients

Graham Thomas, JW Lin, WWM Lam, B Tomlinson, V Yeung, JCN Chan, KS Wong

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    21 Citations (Scopus)

    Abstract

    AIMS/HYPOTHESIS: Albuminuria has been reported to be a marker of cardiovascular risk factors and disease morbidity and mortality, but its relationship with intracerebral atherosclerotic disease is less clear. The aim of this study was to investigate the association between albuminuria and intracranial and extracranial vascular involvement in Chinese Type 2 diabetic patients. METHODS: The anthropometric and fasting biochemical measurements of 966 Type 2 diabetic patients with normoalbuminuria (55.6%), microalbuminuria (27.7%) or macroalbuminuria (16.7%) were compared. The prevalence of microvascular and macrovascular disease and middle cerebral artery (MCA) stenosis, measured by transcranial Doppler ultrasound, were also compared between the groups. RESULTS: Albuminuria was closely associated with a range of adverse parameters, including high BP, dyslipidaemia, smoking and adiposity (all p
    Original languageEnglish
    DOIs
    Publication statusPublished - 1 Sep 2004

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