TY - JOUR
T1 - Development of comprehensive disease assessment in systemic vasculitis
AU - Flossmann, O
AU - Bacon, Paul
AU - de Groot, K
AU - Jayne, DRW
AU - Rasmussen, N
AU - Seo, P
AU - Westman, K
AU - Luqmani, R
PY - 2007/3/1
Y1 - 2007/3/1
N2 - The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.
AB - The systemic vasculitides are multisystem disorders with considerable mortality and morbidity and frequent relapses. In the absence of reliable serological markers, accurate clinical tools are required to assess disease activity and damage for treatment decisions, and for the performance of clinical trials. This article reviews and summarises the development and use of disease assessment tools for determining activity and damage in systemic vasculitis and reports ongoing initiatives for further development of disease assessment tools. A literature search was conducted using PubMed and reference lists for vasculitis, assessment, clinical trials, outcome and prognosis. The findings indicate that comprehensive disease assessment in vasculitis requires documentation of disease activity, chronic irreversible damage and impairment of function.
UR - http://www.scopus.com/inward/record.url?scp=41849144122&partnerID=8YFLogxK
U2 - 10.1136/ard.2005.051078
DO - 10.1136/ard.2005.051078
M3 - Article
C2 - 16728460
SN - 0003-4967
VL - 66
SP - 283
EP - 292
JO - Annals of the Rheumatic Diseases
JF - Annals of the Rheumatic Diseases
IS - 3
ER -