Development of Bioactive Tellurite-Lanthanide Ions-Reinforced Hydroxyapatite composites for biomedical and luminescence applications

Human skeletal bone loss is a major health concern in the twenty-first century, with massive socioeconomic implications. The objective of the current work is to develop and characterize bioactive tellurite glasses for biomedical applications. As so, tellurium oxide- (TeO₂) and lanthanide (Ln³⁺)-doped borate host systems have been developed and incorporated in a hydroxyapatite (HA) matrix, being adequately characterized regarding solid-state parameters and for in vitro biological response. In the proposed work, the following scientific questions will be addressed: Will the reported tellurite-lanthanide (Te-Ln³⁺) host glass-reinforced hydroxyapatite (HA) ceramic materials influence the cell behavior, such as proliferation and differentiation? Does this Te-Ln material show any luminescence response? Further, the research on lanthanide-based materials is promising, with potential application in prospective medical applications. Consequently, investigation into the role of Te-Ln³⁺-HA host scaffold materials for bone repair is a relatively new approach that deserves a special attention.