Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

John Allotey; Nadine Marlin; Ben W Mol; Peter Von Dadelszen; Wessel Ganzevoort; Joost Akkermans; Asif Ahmed; Jane Daniels; Jon Deeks; Khaled Ismail; Ann Marie Barnard; Julie Dodds; Sally Kerry; Carl Moons; Khalid S Khan; Richard D Riley; Shakila Thangaratinam

doi:10.1186/s41512-016-0004-8

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

John Allotey, Nadine Marlin, Ben W Mol, Peter Von Dadelszen, Wessel Ganzevoort, Joost Akkermans, Asif Ahmed, Jane Daniels, Jon Deeks, Khaled Ismail, Ann Marie Barnard, Julie Dodds, Sally Kerry, Carl Moons, Khalid S Khan, Richard D Riley, Shakila Thangaratinam

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management.

Methods: We aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge.

Discussion: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management.

Trial registration: ISRCTN registry, ISRCTN40384046.

Original language	English
Pages (from-to)	6
Journal	Diagnostic and Prognostic Research
Volume	1
DOIs	https://doi.org/10.1186/s41512-016-0004-8
Publication status	Published - 2017

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Allotey, J., Marlin, N., Mol, B. W., Von Dadelszen, P., Ganzevoort, W., Akkermans, J., Ahmed, A., Daniels, J., Deeks, J., Ismail, K., Barnard, A. M., Dodds, J., Kerry, S., Moons, C., Khan, K. S., Riley, R. D., & Thangaratinam, S. (2017). Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study. Diagnostic and Prognostic Research, 1, 6. https://doi.org/10.1186/s41512-016-0004-8

@article{2a7bf455979b4ce8877b6b004a771179,

title = "Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study",

abstract = "Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management.Methods: We aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge.Discussion: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management.Trial registration: ISRCTN registry, ISRCTN40384046.",

author = "John Allotey and Nadine Marlin and Mol, {Ben W} and {Von Dadelszen}, Peter and Wessel Ganzevoort and Joost Akkermans and Asif Ahmed and Jane Daniels and Jon Deeks and Khaled Ismail and Barnard, {Ann Marie} and Julie Dodds and Sally Kerry and Carl Moons and Khan, {Khalid S} and Riley, {Richard D} and Shakila Thangaratinam",

year = "2017",

doi = "10.1186/s41512-016-0004-8",

language = "English",

volume = "1",

pages = "6",

journal = "Diagnostic and Prognostic Research",

issn = "2397-7523",

publisher = "Springer",

}

Allotey, J, Marlin, N, Mol, BW, Von Dadelszen, P, Ganzevoort, W, Akkermans, J, Ahmed, A, Daniels, J, Deeks, J, Ismail, K, Barnard, AM, Dodds, J, Kerry, S, Moons, C, Khan, KS, Riley, RD & Thangaratinam, S 2017, 'Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study', Diagnostic and Prognostic Research, vol. 1, pp. 6. https://doi.org/10.1186/s41512-016-0004-8

TY - JOUR

T1 - Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia

T2 - protocol of the prospective cohort PREP study

AU - Allotey, John

AU - Marlin, Nadine

AU - Mol, Ben W

AU - Von Dadelszen, Peter

AU - Ganzevoort, Wessel

AU - Akkermans, Joost

AU - Ahmed, Asif

AU - Daniels, Jane

AU - Deeks, Jon

AU - Ismail, Khaled

AU - Barnard, Ann Marie

AU - Dodds, Julie

AU - Kerry, Sally

AU - Moons, Carl

AU - Khan, Khalid S

AU - Riley, Richard D

AU - Thangaratinam, Shakila

PY - 2017

Y1 - 2017

N2 - Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management.Methods: We aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge.Discussion: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management.Trial registration: ISRCTN registry, ISRCTN40384046.

AB - Background: Early-onset pre-eclampsia with raised blood pressure and protein in the urine before 34 weeks' gestation is one of the leading causes of maternal deaths in the UK. The benefits to the child from prolonging the pregnancy need to be balanced against the risk of maternal deterioration. Accurate prediction models of risks are needed to plan management.Methods: We aim to undertake a multicentre prospective cohort study (Prediction of Risks in Early onset Pre-eclampsia (PREP)) to develop clinical prediction models in women with early-onset pre-eclampsia, for risk of adverse maternal outcomes by 48 h and by discharge. We will externally validate the models in two independent cohorts with 634 and 216 women. In the secondary analyses, we will assess risk of adverse fetal and neonatal outcomes at birth and by discharge.Discussion: The PREP study will quantify the risk of maternal complications at various time points and provide individualised estimates of overall risk in women with early-onset pre-eclampsia to plan the management.Trial registration: ISRCTN registry, ISRCTN40384046.

U2 - 10.1186/s41512-016-0004-8

DO - 10.1186/s41512-016-0004-8

M3 - Article

C2 - 31093538

SN - 2397-7523

VL - 1

SP - 6

JO - Diagnostic and Prognostic Research

JF - Diagnostic and Prognostic Research

ER -

Development and validation of prediction models for risk of adverse outcomes in women with early-onset pre-eclampsia: protocol of the prospective cohort PREP study

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