Development and characterization of a bio-hybrid skin-like stretchable electrode

E Buselli, A Smith, Liam Grover, A Levi, R Allman, V Mattoli, A Menciassi, L Beccai

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9 Citations (Scopus)


This work presents the design, fabrication and characterization of a polymer based stretchable electrode for cell monitoring. The final goal is the development of innovative bio-hybrid skin-like tactile sensors with mammalian cells as core biological elements; to achieve such aim the enabling technological approach is pursued in this investigation. Electrodes are needed to detect cells response, thus the first step of the bio-hybrid system fabrication is the development of a platform able to record such response and transmit it to the external world. The stretchable electrode is composed by a conductive layer (few A of Ti plus 90 nm of Au) on a polymeric substrate (1 mm thick PDMS membrane). Cellular adhesion was verified and cellular response to an induced electrode strain of 1% was detected through fluorescence microscopy. Fluorescence intensities were 104.82 +/- 9.64 a.u. and 129.66 +/- 13.06 a.u. prior and during electrode strain, respectively. Electromechanical characterization of the stretchable electrode revealed excellent stability and reliability within the 1% strain, which is the operative range identified for the future tactile sensor application. Results showed that the electrode was conductive up to 14% of strain. Furthermore, frequency impedance measurements demonstrated the electrode capability of detecting presence of cells. (C) 2010 Elsevier B.V. All rights reserved.
Original languageEnglish
Pages (from-to)1676-1680
Number of pages5
JournalMicroelectronic Engineering
Issue number8
Publication statusPublished - 1 Aug 2011


  • Bio-hybrid
  • Stretchable electrodes
  • Tactile sensors
  • Cell culture
  • Skin-like


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