Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

RA Anderson; GR Ellis; YY Chirkov; AS Holmes; N Payne; DJ Blackman; SK Jackson; MJ Lewis; JD Horowitz; Michael Frenneaux

doi:10.1016/S1388-9842(03)00038-2

Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

RA Anderson, GR Ellis, YY Chirkov, AS Holmes, N Payne, DJ Blackman, SK Jackson, MJ Lewis, JD Horowitz, Michael Frenneaux

Birmingham Medical School

Research output: Contribution to journal › Article

28 Citations (Scopus)

Abstract

Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood-superoxide anion content were determined, with correlates of responsiveness to SNP Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O-2(-) in CHF patients. However, subsets of CHF patients have NO resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

Original language	English
Pages (from-to)	47-54
Number of pages	8
Journal	European Journal of Heart Failure
Volume	6
Issue number	1
DOIs	https://doi.org/10.1016/S1388-9842(03)00038-2
Publication status	Published - 1 Jan 2004

Keywords

platelets
heart failure
free radicals

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10.1016/S1388-9842(03)00038-2

Cite this

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abstract = "Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood-superoxide anion content were determined, with correlates of responsiveness to SNP Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O-2(-) in CHF patients. However, subsets of CHF patients have NO resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p",

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AU - Anderson, RA

AU - Ellis, GR

AU - Chirkov, YY

AU - Holmes, AS

AU - Payne, N

AU - Blackman, DJ

AU - Jackson, SK

AU - Lewis, MJ

AU - Horowitz, JD

AU - Frenneaux, Michael

PY - 2004/1/1

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N2 - Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood-superoxide anion content were determined, with correlates of responsiveness to SNP Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O-2(-) in CHF patients. However, subsets of CHF patients have NO resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

AB - Congestive heart failure (CHF) is associated with oxidative stress. Platelet responsiveness to nitric oxide (NO) donors, are impaired in patients with angina pectoris, possibly by increasing oxidative stress. We investigated the occurrence of platelet resistance to NO in patients, with ischaemic or non-ischaemic cardiomyopathy compared with normal subjects. Anti-aggregatory effects of sodium nitroprusside (SNP), oxidative stress and whole blood-superoxide anion content were determined, with correlates of responsiveness to SNP Inhibition of platelet aggregation by SNP was 65.4+/-3.55% in controls and 59.3+/-4.1% in CHF (P=ns) despite increased oxidative stress and post-aggregation O-2(-) in CHF patients. However, subsets of CHF patients have NO resistant platelets: this is associated with increasing age and/or increased oxidative stress (both p

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Determinants of platelet responsiveness to nitric oxide in patients with chronic heart failure

Abstract

Keywords

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