Determinants of ELAV gene-specific regulation

Matthias Soller, Min Li, Irmgard Haussmann

Research output: Contribution to journalArticle

8 Citations (Scopus)


How RNA-binding proteins recognize their complement of targets in a complex cellular environment remains poorly understood. Sequence degeneracy and redundancy of short motifs at genomic scales have mostly eluded predictions of specific target genes for gene-specific ELAV (embryonic lethal abnormal visual system)/Hu proteins that bind ubiquitous AU-rich motifs. Using the genetic tools of Drosophila, we have analysed binding properties of ELAV in vitro and ELAV-dependent regulation of its major target ewg (erect wing) in neurons. These studies reveal that an integral part of ELAV gene-specific regulation involves combinatorial binding to variably spaced short U-rich motifs on an extensive binding site.
Original languageEnglish
Pages (from-to)1122-1124
Number of pages3
JournalBiochemical Society Transactions
Publication statusPublished - 1 Aug 2010


  • nervous system development
  • alternative polyadenylation
  • embryonic lethal abnormal visual system (ELAV)
  • alternative splicing


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