Detection of MAGE-A expression predicts malignant transformation of oral leukoplakia

Jutta Ries, Abbas Agaimy, Elefterios Vairaktaris, Patricia Gorecki, Friedrich W Neukam, Lei H Strassburg, Emeka Nkenke

Research output: Contribution to journalArticlepeer-review

12 Citations (Scopus)

Abstract

The study aimed at checking if MAGE-A expression in oral leukoplakia (OLP) lesions is related to malignant transformation. The 48 samples of OLP that transformed to oral squamous cell carcinoma (OSCC) (group 1) and 50 samples of OLP that did not transform to OSCC (group 2) were included in the study. The expression of MAGE-A was restricted to group 1. The correlation between malignant transformation and MAGE-A occurrence in OLP was statistically significant (p <.0001). Detection of MAGE-A may allow identifying OLP with a high risk of malignant transformation giving a view to a new approach to prevention of oral cancer.
Original languageEnglish
Pages (from-to)495-502
Number of pages8
JournalCancer investigation
Volume30
Issue number7
DOIs
Publication statusPublished - Aug 2012

Keywords

  • Leukoplakia, Oral
  • Mouth Mucosa
  • Humans
  • Middle Aged
  • Carcinoma, Squamous Cell
  • Mouth Neoplasms
  • Immunohistochemistry
  • Melanoma-Specific Antigens
  • Male
  • Female
  • Cell Transformation, Neoplastic

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