Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.

JL Duprey; ZY Zhao; DM Bassani; Jack Manchester; JS Vyle; James Tucker

doi:10.1039/c1cc11205h

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.

JL Duprey, ZY Zhao, DM Bassani, Jack Manchester, JS Vyle, James Tucker

Chemistry

Research output: Contribution to journal › Article

22 Citations (Scopus)

Abstract

A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

Original language	English
Journal	Chemical Communications
DOIs	https://doi.org/10.1039/c1cc11205h
Publication status	Published - 12 May 2011

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10.1039/c1cc11205h

Functional DNA-based assemblies
Tucker, J. (Principal Investigator)
Engineering & Physical Science Research Council
16/03/09 → 31/03/14
Project: Research Councils

Cite this

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title = "Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.",

abstract = "A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.",

author = "JL Duprey and ZY Zhao and DM Bassani and Jack Manchester and JS Vyle and James Tucker",

year = "2011",

month = may,

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doi = "10.1039/c1cc11205h",

language = "English",

journal = "Chemical Communications",

issn = "1364-548X",

publisher = "Royal Society of Chemistry",

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AU - Duprey, JL

AU - Zhao, ZY

AU - Bassani, DM

AU - Manchester, Jack

AU - Vyle, JS

AU - Tucker, James

PY - 2011/5/12

Y1 - 2011/5/12

N2 - A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

AB - A fluorescent DNA probe containing an anthracene group attached via an anucleosidic linker can identify all four DNA bases at a single site as well as the epigenetic modification C/5-MeC via a hybridisation sensing assay.

U2 - 10.1039/c1cc11205h

DO - 10.1039/c1cc11205h

M3 - Article

C2 - 21562680

SN - 1364-548X

JO - Chemical Communications

JF - Chemical Communications

ER -

Detection of DNA base variation and cytosine methylation at a single nucleotide site using a highly sensitive fluorescent probe.

Abstract

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Functional DNA-based assemblies

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