Desmosomal cadherins

Martyn Chidgey, David Garrod

Research output: Chapter in Book/Report/Conference proceedingChapter

1 Citation (Scopus)


The desmosomal cadherins (DCs) are adhesion molecules of desmosomes,
intercellular junctions of epithelia and cardiac muscle. DCs have the unique
ability to adopt a hyperadhesive state that is characterised by enhanced stability and adhesive strength. Hyperadhesion is important in embryonic development and wound healing, and DC expression is tightly regulated at the transcriptional and posttranslational levels. Desmosomes act as signalling centres and DCs have been linked to an array of intracellular signal transduction pathways that control cell proliferation and differentiation. DCs are targets of autoantibodies, bacterial toxins and mutations, resulting in skin blistering disease, cardiomyopathy and sometimes both. Here we consider the structure and function of the desmosomal cadherins, and their role in normal tissue biology and human disease.
Original languageEnglish
Title of host publicationThe Cadherin Superfamily
Subtitle of host publicationKey Regulators of Animal Development and Physiology
EditorsShintaro T Suzuki, Shinji Hirano
Number of pages35
ISBN (Electronic)9784431560333
ISBN (Print)9784431560319
Publication statusPublished - 2016


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