Desmocollin switching in colorectal cancer

Katherina Khan, Rowan Hardy, A Haq, O Ogunbiyi, Dion Morton, Martyn Chidgey

Research output: Contribution to journalArticle

57 Citations (Scopus)


The desmocollins are members of the desmosomal cadherin family of cell-cell adhesion molecules. They are essential constituents of desmosomes, intercellular junctions that play a critical role in the maintenance of tissue integrity in epithelia and cardiac muscle. In humans, three desmocollins (Dsc1, Dsc2 and Dsc3) have been described. The desmocollins exhibit tissue-specific patterns of expression; only Dsc2 is expressed in normal colonic epithelium. We have found switching between desmocollins in sporadic colorectal adenocarcinoma with a reduction in Dsc2 protein (in 8/16 samples analysed by immunohistochemistry) being accompanied by de novo expression of Dsc1 (16/16) and Dsc3 (7/16). Similar results were obtained by western blotting of a further 16 samples. No change was found in Dsc2 mRNA, but de novo expression of Dscs 1 and 3 was accompanied by increased message levels. Loss of Dsc2 (8/19) and de novo expression of Dsc1 (11/19) and Dsc3 (6/19) was also found in colorectal adenocarcinomas on a background of colitis. The data raise the possibility that switching of desmocollins could play an important role in the development of colorectal cancer.
Original languageEnglish
Pages (from-to)1367-1370
Number of pages4
JournalBritish Journal of Cancer
Publication statusPublished - 31 Oct 2006


  • desmosome
  • cadherin
  • colorectal cancer
  • desmocollin


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