Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs

Adam Kolodziej, Cecile Le Duff, Julián Bergueiro, Marc Walker, Alexander Keeler, Andrea Russell, Francisco Fernandez-Trillo, Paramaconi Rodriguez

Research output: Contribution to journalArticlepeer-review

92 Downloads (Pure)

Abstract

The design of a hemofiltration method that minimizes the side effects produced by the accumulation of Pt-based drugs such as cisplatin represents an important technology for cancer treatment. This work establishes the foundation for the development of an efficient platform for the electrochemical hemofiltration and simultaneous sensing of antitumor drugs, such as cisplatin and carboplatin, from physiological medium. The electrochemical filtration system is based on a gold surface-modified electrode using tris(carboxyethyl)phosphine ligands as scavengers of the Pt-based drug complexes. The platinum-phosphine interaction is shown to be more time efficient, as compared to the naturally occurring form of a glutathione-platinum adduct, and displayed a highly cooperative nature of binding. Altogether, we demonstrate that the presence of ligands capable of binding to Pt results in a differential spectroscopic and electrochemical response and the potential to adsorb and monitor the concentration of Pt salts in complex aqueous media.

Original languageEnglish
Pages (from-to)8012-8018
Number of pages7
JournalChemistry of Materials
Volume31
Issue number19
DOIs
Publication statusPublished - 8 Oct 2019

ASJC Scopus subject areas

  • Chemistry(all)
  • Chemical Engineering(all)
  • Materials Chemistry

Fingerprint

Dive into the research topics of 'Design of surface-modified electrodes for the electrochemical adsorption of Platinum-based anticancer drugs'. Together they form a unique fingerprint.

Cite this