Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

L Cardo; Michael Hannon

doi:10.1016/j.ica.2008.02.050

Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

L Cardo, Michael Hannon

Chemistry

Research output: Contribution to journal › Article

21 Citations (Scopus)

Abstract

Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.

Original language	English
Pages (from-to)	784-792
Number of pages	9
Journal	Inorganica Chimica Acta
Volume	362
Issue number	3
DOIs	https://doi.org/10.1016/j.ica.2008.02.050
Publication status	Published - 1 Feb 2009

Keywords

DNA-binding
Supramolecular cylinders
Artificial nuclease
Peptide functionalisation
DNA coiling
Bioinorganic chemistry
Metallo-supramolecular chemistry

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10.1016/j.ica.2008.02.050

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title = "Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides",

abstract = "Di-nuclear metallo-supramolecular {"}cylinders{"}, based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.",

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T1 - Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

AU - Cardo, L

AU - Hannon, Michael

PY - 2009/2/1

Y1 - 2009/2/1

N2 - Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.

AB - Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.

KW - DNA-binding

KW - Supramolecular cylinders

KW - Artificial nuclease

KW - Peptide functionalisation

KW - DNA coiling

KW - Bioinorganic chemistry

KW - Metallo-supramolecular chemistry

U2 - 10.1016/j.ica.2008.02.050

DO - 10.1016/j.ica.2008.02.050

M3 - Article

VL - 362

SP - 784

EP - 792

JO - Inorganica Chimica Acta

JF - Inorganica Chimica Acta

IS - 3

ER -

Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

Abstract

Keywords

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