Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides

Research output: Contribution to journalArticle

21 Citations (Scopus)


Di-nuclear metallo-supramolecular "cylinders", based on bis-pyridylimine ligands, are end-functionalised with short peptides. The design and synthesis of one tetra-cationic triple-stranded (iron(II)) and three di-cationic double-stranded (copper(I) or silver(I)) cylinder-peptide conjugates are described. DNA-binding experiments, using circular and linear dichroism spectroscopies, confirm the binding and indicate that the iron(II) complexes cause DNA to bend or coil. Artificial nuclease activity by the copper(I) complexes is demonstrated by gel electrophoresis studies. (C) 2008 Elsevier B. V. All rights reserved.
Original languageEnglish
Pages (from-to)784-792
Number of pages9
JournalInorganica Chimica Acta
Issue number3
Publication statusPublished - 1 Feb 2009


  • DNA-binding
  • Supramolecular cylinders
  • Artificial nuclease
  • Peptide functionalisation
  • DNA coiling
  • Bioinorganic chemistry
  • Metallo-supramolecular chemistry


Dive into the research topics of 'Design and DNA-binding of metallo-supramolecular cylinders conjugated to peptides'. Together they form a unique fingerprint.

Cite this