Depression and schizophrenia: cause, consequence or trans-diagnostic issue?

Rachel Upthegrove; Steven Marwaha; Max Birchwood

doi:10.1093/schbul/sbw097

Depression and schizophrenia: cause, consequence or trans-diagnostic issue?

Rachel Upthegrove, Steven Marwaha, Max Birchwood

Research output: Contribution to journal › Review article › peer-review

135 Citations (Scopus)

310 Downloads (Pure)

Abstract

The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.

Original language	English
Pages (from-to)	240-244
Number of pages	5
Journal	Schizophrenia bulletin
Volume	43
Issue number	2
Early online date	15 Jul 2016
DOIs	https://doi.org/10.1093/schbul/sbw097
Publication status	Published - 1 Mar 2017

Keywords

Comorbidity
Depressive Disorder/epidemiology
Humans
Psychotic Disorders/complications
Schizophrenia/complications

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10.1093/schbul/sbw097

Depression_SB_final_for_PURE
This is a pre-copy-editing, author-produced PDF of an article accepted for publication in Schizophrenia Bulletin following peer review. The definitive publisher-authenticated version Upthegrove, Rachel, Steven Marwaha, and Max Birchwood. "Depression and schizophrenia: cause, consequence or trans-diagnostic issue?." Schizophrenia Bulletin (2016) is available online at: http://schizophreniabulletin.oxfordjournals.org/content/early/2016/07/15/schbul.sbw097.short
Accepted author manuscript, 153 KBLicence: None: All rights reserved

135 Citations
1 Article

Treatment of depression in schizophrenia: a systematic review and meta-analysis
Gregory, A., Mallikarjun, P. & Upthegrove, R., 1 Oct 2017, In: British Journal of Psychiatry . 211, 4, p. 198-204 7 p.
Research output: Contribution to journal › Article › peer-review

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36 Citations (Scopus)

257 Downloads (Pure)

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title = "Depression and schizophrenia: cause, consequence or trans-diagnostic issue?",

abstract = "The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.",

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author = "Rachel Upthegrove and Steven Marwaha and Max Birchwood",

note = "{\textcopyright} The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: [email protected].",

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doi = "10.1093/schbul/sbw097",

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T2 - cause, consequence or trans-diagnostic issue?

AU - Upthegrove, Rachel

AU - Marwaha, Steven

AU - Birchwood, Max

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N2 - The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.

AB - The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.

KW - Comorbidity

KW - Depressive Disorder/epidemiology

KW - Humans

KW - Psychotic Disorders/complications

KW - Schizophrenia/complications

U2 - 10.1093/schbul/sbw097

DO - 10.1093/schbul/sbw097

M3 - Review article

C2 - 27421793

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VL - 43

SP - 240

EP - 244

JO - Schizophrenia bulletin

JF - Schizophrenia bulletin

IS - 2

ER -

Depression and schizophrenia: cause, consequence or trans-diagnostic issue?

Abstract

Keywords

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Research output

Treatment of depression in schizophrenia: a systematic review and meta-analysis

Cite this