Depression and schizophrenia: cause, consequence or trans-diagnostic issue?

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The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.
Original languageEnglish
Pages (from-to)240-244
Number of pages5
JournalSchizophrenia bulletin
Issue number2
Early online date15 Jul 2016
Publication statusPublished - 1 Mar 2017


  • Comorbidity
  • Depressive Disorder/epidemiology
  • Humans
  • Psychotic Disorders/complications
  • Schizophrenia/complications


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