TY - JOUR
T1 - Depression and schizophrenia
T2 - cause, consequence or trans-diagnostic issue?
AU - Upthegrove, Rachel
AU - Marwaha, Steven
AU - Birchwood, Max
N1 - © The Author 2016. Published by Oxford University Press on behalf of the Maryland Psychiatric Research Center. All rights reserved. For permissions, please email: [email protected].
PY - 2017/3/1
Y1 - 2017/3/1
N2 - The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.
AB - The presence of depression in schizophrenia has been a challenge to the Kraepelinian dichotomy, with various attempts to save the fundamental distinction including evoking and refining diagnoses such as schizoaffective disorder. But the tectonic plates are shifting. Here we put forward a summary of recent evidence regarding the prevalence, importance, possible aetiological pathways and treatment challenges that recognising depression in schizophrenia bring. Taken together we propose that depression is more than co-morbidity and that increased effective therapeutic attention to mood symptoms will be needed to improve outcomes and to support prevention.
KW - Comorbidity
KW - Depressive Disorder/epidemiology
KW - Humans
KW - Psychotic Disorders/complications
KW - Schizophrenia/complications
U2 - 10.1093/schbul/sbw097
DO - 10.1093/schbul/sbw097
M3 - Review article
C2 - 27421793
SN - 0586-7614
VL - 43
SP - 240
EP - 244
JO - Schizophrenia bulletin
JF - Schizophrenia bulletin
IS - 2
ER -