Dendritic Cells, BAFF, and APRIL: Innate players in adaptive antibody responses

Ian MacLennan, CG Vinuesa

Research output: Contribution to journalArticle

137 Citations (Scopus)

Abstract

The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
Original languageEnglish
Pages (from-to)235-38
Number of pages4
JournalImmunity
Volume17
DOIs
Publication statusPublished - 1 Jan 2002

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