Abstract
The first antibody produced in bacterial or viral infection results from B cell growth as plasmablasts. Dendritic cell-derived TNF-family ligands APRIL and/or BAFF plasmablast survival and differentiation to plasma cells. Expression of these ligands by dendritic cells is promoted by innate immune signals that can convert subliminal B cell activation to a productive response. While this may be lifesaving in the face of infection, it can predispose to autoantibody production.
Original language | English |
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Pages (from-to) | 235-38 |
Number of pages | 4 |
Journal | Immunity |
Volume | 17 |
DOIs | |
Publication status | Published - 1 Jan 2002 |