Demystified ... Human endogenous retroviruses

PN Nelson, PR Carnegie, J Martin, HD Ejtehadi, P Hooley, D Roden, S Rowland-Jones, P Warren, J Astley, Paul Murray

Research output: Contribution to journalReview article

124 Citations (Scopus)


Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.
Original languageEnglish
Pages (from-to)11-18
Number of pages8
JournalMolecular Pathology
Issue number1
Publication statusPublished - 1 Feb 2003


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