Demystified ... Human endogenous retroviruses

PN Nelson; PR Carnegie; J Martin; HD Ejtehadi; P Hooley; D Roden; S Rowland-Jones; P Warren; J Astley; Paul Murray

doi:10.1136/mp.56.1.11

Demystified ... Human endogenous retroviruses

PN Nelson, PR Carnegie, J Martin, HD Ejtehadi, P Hooley, D Roden, S Rowland-Jones, P Warren, J Astley, Paul Murray

Cancer and Genomic Sciences

Research output: Contribution to journal › Review article

124 Citations (Scopus)

Abstract

Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

Original language	English
Pages (from-to)	11-18
Number of pages	8
Journal	Molecular Pathology
Volume	56
Issue number	1
DOIs	https://doi.org/10.1136/mp.56.1.11
Publication status	Published - 1 Feb 2003

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10.1136/mp.56.1.11

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AU - Martin, J

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AU - Hooley, P

AU - Roden, D

AU - Rowland-Jones, S

AU - Warren, P

AU - Astley, J

AU - Murray, Paul

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AB - Human endogenous retroviruses (HERVs) are a family of viruses within our genome with similarities to present day exogenous retroviruses. HERVs have been inherited by successive generations and it is possible that some have conferred biological benefits. However, several HERVs have been implicated in certain cancers and autoimmune diseases. This article demystifies these retroviruses by providing an insight into HERVs, their means of classification, and a synopsis of HERVs implicated in cancer and autoimmunity. Furthermore, the biological roles of HERVs are explored.

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Demystified ... Human endogenous retroviruses

Abstract

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