Delta 32 deletion of CCR5 gene and association with asthma or atopy

T J Mitchell, A J Walley, J E Pease, P J Venables, S Wiltshire, T J Williams, W O Cookson

Research output: Contribution to journalArticlepeer-review

45 Citations (Scopus)

Abstract

The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.

Original languageEnglish
Pages (from-to)1491-2
Number of pages2
JournalThe Lancet
Volume356
Issue number9240
DOIs
Publication statusPublished - 28 Oct 2000

Keywords

  • Alleles
  • Asthma
  • DNA
  • Family
  • Family Health
  • Female
  • Gene Frequency
  • Genotype
  • Great Britain
  • Humans
  • Hypersensitivity, Immediate
  • Male
  • Polymorphism, Genetic
  • Receptors, CCR5
  • Sequence Deletion
  • Western Australia

Fingerprint

Dive into the research topics of 'Delta 32 deletion of CCR5 gene and association with asthma or atopy'. Together they form a unique fingerprint.

Cite this