Delta 32 deletion of CCR5 gene and association with asthma or atopy

T J Mitchell; A J Walley; J E Pease; P J Venables; S Wiltshire; T J Williams; W O Cookson

doi:10.1016/S0140-6736(00)03144-5

Delta 32 deletion of CCR5 gene and association with asthma or atopy

T J Mitchell, A J Walley, J E Pease, P J Venables, S Wiltshire, T J Williams, W O Cookson

Microbes, Infections and Microbiomes

Research output: Contribution to journal › Article › peer-review

45 Citations (Scopus)

Abstract

The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.

Original language	English
Pages (from-to)	1491-2
Number of pages	2
Journal	The Lancet
Volume	356
Issue number	9240
DOIs	https://doi.org/10.1016/S0140-6736(00)03144-5
Publication status	Published - 28 Oct 2000

Keywords

Alleles
Asthma
DNA
Family
Family Health
Female
Gene Frequency
Genotype
Great Britain
Humans
Hypersensitivity, Immediate
Male
Polymorphism, Genetic
Receptors, CCR5
Sequence Deletion
Western Australia

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10.1016/S0140-6736(00)03144-5

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title = "Delta 32 deletion of CCR5 gene and association with asthma or atopy",

abstract = "The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.",

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T1 - Delta 32 deletion of CCR5 gene and association with asthma or atopy

AU - Mitchell, T J

AU - Walley, A J

AU - Pease, J E

AU - Venables, P J

AU - Wiltshire, S

AU - Williams, T J

AU - Cookson, W O

PY - 2000/10/28

Y1 - 2000/10/28

N2 - The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.

AB - The CCR5-delta32 deletion polymorphism (CCR5-delta32) was investigated for linkage and association to asthma and atopy using two panels of nuclear families containing 1284 individuals. No statistically significant linkage to asthma/wheeze or atopy was observed in either of the two panels of families. Multiallelic transmission disequilibrium tests (TDT) of the combined data found no significant association for atopy (52 independent alleles transmitted, 51 non-transmitted) or asthma/wheeze (39 transmitted, 44 non-transmitted). Although functional evidence might suggest that CCR5 is a good candidate gene for atopic asthma, this study provides no genetic evidence from CCR5-delta32 polymorphism to support this hypothesis.

KW - Alleles

KW - Asthma

KW - DNA

KW - Family

KW - Family Health

KW - Female

KW - Gene Frequency

KW - Genotype

KW - Great Britain

KW - Humans

KW - Hypersensitivity, Immediate

KW - Male

KW - Polymorphism, Genetic

KW - Receptors, CCR5

KW - Sequence Deletion

KW - Western Australia

U2 - 10.1016/S0140-6736(00)03144-5

DO - 10.1016/S0140-6736(00)03144-5

M3 - Article

C2 - 11081537

SN - 0140-6736

VL - 356

SP - 1491

EP - 1492

JO - The Lancet

JF - The Lancet

IS - 9240

ER -

Delta 32 deletion of CCR5 gene and association with asthma or atopy

Abstract

Keywords

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