Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T Al-Jamal; Antonio Nunes; Laura Methven; Hanene Ali-Boucetta; Shouping Li; Francesca M Toma; M Antonia Herrero; Wafa' T Al-Jamal; Huub M M ten Eikelder; Julie Foster; Stephen Mather; Maurizio Prato; Alberto Bianco; Kostas Kostarelos

doi:10.1002/anie.201201991

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Khuloud T Al-Jamal, Antonio Nunes, Laura Methven, Hanene Ali-Boucetta, Shouping Li, Francesca M Toma, M Antonia Herrero, Wafa' T Al-Jamal, Huub M M ten Eikelder, Julie Foster, Stephen Mather, Maurizio Prato, Alberto Bianco, Kostas Kostarelos

Pharmacy

Research output: Contribution to journal › Article › peer-review

111 Citations (Scopus)

Abstract

Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

Original language	English
Pages (from-to)	6389-93
Number of pages	5
Journal	Angewandte Chemie (International Edition)
Volume	51
Issue number	26
DOIs	https://doi.org/10.1002/anie.201201991
Publication status	Published - 25 Jun 2012

Keywords

Amines/chemistry
Animals
Mice
Microscopy, Electron, Transmission
Models, Molecular
Molecular Structure
Nanotubes, Carbon/chemistry
Organ Specificity

Access to Document

10.1002/anie.201201991

Cite this

Al-Jamal, K. T., Nunes, A., Methven, L., Ali-Boucetta, H., Li, S., Toma, F. M., Herrero, M. A., Al-Jamal, W. T., ten Eikelder, H. M. M., Foster, J., Mather, S., Prato, M., Bianco, A., & Kostarelos, K. (2012). Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile. Angewandte Chemie (International Edition) , 51(26), 6389-93. https://doi.org/10.1002/anie.201201991

@article{220b8115b3de4e918ce8f80a2d4d9e2f,

title = "Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile",

abstract = "Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.",

keywords = "Amines/chemistry, Animals, Mice, Microscopy, Electron, Transmission, Models, Molecular, Molecular Structure, Nanotubes, Carbon/chemistry, Organ Specificity",

author = "Al-Jamal, {Khuloud T} and Antonio Nunes and Laura Methven and Hanene Ali-Boucetta and Shouping Li and Toma, {Francesca M} and Herrero, {M Antonia} and Al-Jamal, {Wafa' T} and {ten Eikelder}, {Huub M M} and Julie Foster and Stephen Mather and Maurizio Prato and Alberto Bianco and Kostas Kostarelos",

note = "Copyright {\textcopyright} 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.",

year = "2012",

month = jun,

day = "25",

doi = "10.1002/anie.201201991",

language = "English",

volume = "51",

pages = "6389--93",

journal = "Angewandte Chemie (International Edition) ",

issn = "1433-7851",

publisher = "Wiley-VCH Verlag",

number = "26",

}

Al-Jamal, KT, Nunes, A, Methven, L, Ali-Boucetta, H, Li, S, Toma, FM, Herrero, MA, Al-Jamal, WT, ten Eikelder, HMM, Foster, J, Mather, S, Prato, M, Bianco, A & Kostarelos, K 2012, 'Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile', Angewandte Chemie (International Edition) , vol. 51, no. 26, pp. 6389-93. https://doi.org/10.1002/anie.201201991

TY - JOUR

T1 - Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

AU - Al-Jamal, Khuloud T

AU - Nunes, Antonio

AU - Methven, Laura

AU - Ali-Boucetta, Hanene

AU - Li, Shouping

AU - Toma, Francesca M

AU - Herrero, M Antonia

AU - Al-Jamal, Wafa' T

AU - ten Eikelder, Huub M M

AU - Foster, Julie

AU - Mather, Stephen

AU - Prato, Maurizio

AU - Bianco, Alberto

AU - Kostarelos, Kostas

PY - 2012/6/25

Y1 - 2012/6/25

N2 - Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

AB - Getting rid of the tubes: An assessment of the retention of functionalized multi-walled carbon nanotubes (MWNTs) in the organs of mice was carried out using single photon emission computed tomography and quantitative scintigraphy (see scheme). Increasing the degree of functionalization on MWNTs enhanced renal clearance, while lower functionalization promoted reticuloendethelial system accumulation.

KW - Amines/chemistry

KW - Animals

KW - Mice

KW - Microscopy, Electron, Transmission

KW - Models, Molecular

KW - Molecular Structure

KW - Nanotubes, Carbon/chemistry

KW - Organ Specificity

U2 - 10.1002/anie.201201991

DO - 10.1002/anie.201201991

M3 - Article

C2 - 22623333

SN - 1433-7851

VL - 51

SP - 6389

EP - 6393

JO - Angewandte Chemie (International Edition)

JF - Angewandte Chemie (International Edition)

IS - 26

ER -

Degree of chemical functionalization of carbon nanotubes determines tissue distribution and excretion profile

Abstract

Keywords

Access to Document

Fingerprint

Cite this