Degeneracy: A design principle for achieving robustness and evolvability

James Whitacre, A Bender

Research output: Contribution to journalArticle

103 Citations (Scopus)

Abstract

Robustness, the insensitivity of some of a biological system's functionalities to a set of distinct conditions, is intimately linked to fitness. Recent studies suggest that it may also play a vital role in enabling the evolution of species. Increasing robustness, so is proposed, can lead to the emergence of evolvability if evolution proceeds over a neutral network that extends far throughout the fitness landscape. Here, we show that the design principles used to achieve robustness dramatically influence whether robustness leads to evolvability. In simulation experiments, we find that purely redundant systems have remarkably low evolvability while degenerate, i.e. partially redundant, systems tend to be orders of magnitude more evolvable. Surprisingly, the magnitude of observed variation in evolvability can neither be explained by differences in the size nor the topology of the neutral networks. This suggests that degeneracy, a ubiquitous characteristic in biological systems, may be an important enabler of natural evolution. More generally, our study provides valuable new clues about the origin of innovations in complex adaptive systems.
Original languageEnglish
Pages (from-to)143-153
Number of pages11
JournalJournal of Theoretical Biology
Volume263
Issue number1
Early online date17 Nov 2009
DOIs
Publication statusPublished - 7 Mar 2010

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