Defining an epigenetic code

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264 Citations (Scopus)


The nucleosome surface is decorated with an array of enzyme-catalysed modifications on histone tails. These modifications have well-defined roles in a variety of ongoing chromatin functions, often by acting as receptors for non-histone proteins, but their longer-term effects are less clear. Here, an attempt is made to define how histone modifications operate as part of a predictive and heritable epigenetic code that specifies patterns of gene expression through differentiation and development.
Original languageEnglish
Pages (from-to)2-6
Number of pages5
JournalNature Cell Biology
Publication statusPublished - 1 Jan 2007


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