Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

M Figee; J Luigjes; R Smolders; CE Valencia-Alfonso; Wingen G van; Kwaasteniet B de; M Mantione; P Ooms; Koning P de; N Vulink; N Levar; L Droge; den Munckhof P van; PR Schuurman; A Nederveen; den Brink W van; A Mazaheri; M Vink; D Denys

doi:10.1038/nn.3344

Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

M Figee, J Luigjes, R Smolders, CE Valencia-Alfonso, Wingen G van, Kwaasteniet B de, M Mantione, P Ooms, Koning P de, N Vulink, N Levar, L Droge, den Munckhof P van, PR Schuurman, A Nederveen, den Brink W van, A Mazaheri, M Vink, D Denys

Psychology

Research output: Contribution to journal › Article › peer-review

Abstract

Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.

Original language	English
Pages (from-to)	386-387
Journal	Nature Neuroscience
Volume	16
DOIs	https://doi.org/10.1038/nn.3344
Publication status	Published - Apr 2013

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Figee, M., Luigjes, J., Smolders, R., Valencia-Alfonso, CE., van, W. G., de, K. B., Mantione, M., Ooms, P., de, K. P., Vulink, N., Levar, N., Droge, L., van, D. M. P., Schuurman, PR., Nederveen, A., van, D. B. W., Mazaheri, A., Vink, M., & Denys, D. (2013). Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder. Nature Neuroscience, 16, 386-387. https://doi.org/10.1038/nn.3344

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title = "Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.",

abstract = "Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.",

author = "M Figee and J Luigjes and R Smolders and CE Valencia-Alfonso and van, {Wingen G} and de, {Kwaasteniet B} and M Mantione and P Ooms and de, {Koning P} and N Vulink and N Levar and L Droge and van, {den Munckhof P} and PR Schuurman and A Nederveen and van, {den Brink W} and A Mazaheri and M Vink and D Denys",

year = "2013",

month = apr,

doi = "10.1038/nn.3344",

language = "English",

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journal = "Nature Neuroscience",

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Figee, M, Luigjes, J, Smolders, R, Valencia-Alfonso, CE, van, WG, de, KB, Mantione, M, Ooms, P, de, KP, Vulink, N, Levar, N, Droge, L, van, DMP, Schuurman, PR, Nederveen, A, van, DBW, Mazaheri, A, Vink, M & Denys, D 2013, 'Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.', Nature Neuroscience, vol. 16, pp. 386-387. https://doi.org/10.1038/nn.3344

TY - JOUR

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AU - Figee, M

AU - Luigjes, J

AU - Smolders, R

AU - Valencia-Alfonso, CE

AU - van, Wingen G

AU - de, Kwaasteniet B

AU - Mantione, M

AU - Ooms, P

AU - de, Koning P

AU - Vulink, N

AU - Levar, N

AU - Droge, L

AU - van, den Munckhof P

AU - Schuurman, PR

AU - Nederveen, A

AU - van, den Brink W

AU - Mazaheri, A

AU - Vink, M

AU - Denys, D

PY - 2013/4

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N2 - Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.

AB - Little is known about the underlying neural mechanism of deep brain stimulation (DBS). We found that DBS targeted at the nucleus accumbens (NAc) normalized NAc activity, reduced excessive connectivity between the NAc and prefrontal cortex, and decreased frontal low-frequency oscillations during symptom provocation in patients with obsessive-compulsive disorder. Our findings suggest that DBS is able to reduce maladaptive activity and connectivity of the stimulated region.

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VL - 16

SP - 386

EP - 387

JO - Nature Neuroscience

JF - Nature Neuroscience

ER -

Deep brain stimulation restores frontostriatal network activity in obsessive-compulsive disorder.

Abstract

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