Deep brain stimulation for tremor resulting from acquired brain injury

H A Sitsapesan, P Holland, Z Oliphant, N De Pennington, J-S Brittain, N Jenkinson, C Joint, T Z Aziz, A L Green

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12 Citations (Scopus)
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OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).

METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.

RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.

CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

Original languageEnglish
Pages (from-to)811-5
Number of pages5
JournalJournal of Neurology Neurosurgery and Psychiatry
Issue number7
Publication statusPublished - Jul 2014

Bibliographical note

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to


  • Adult
  • Aged
  • Brain Injuries
  • Deep Brain Stimulation
  • Electrodes, Implanted
  • Female
  • Humans
  • Male
  • Severity of Illness Index
  • Single-Blind Method
  • Treatment Outcome
  • Tremor
  • Young Adult


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