Deep brain stimulation for tremor resulting from acquired brain injury

H A Sitsapesan; P Holland; Z Oliphant; N De Pennington; J-S Brittain; N Jenkinson; C Joint; T Z Aziz; A L Green

doi:10.1136/jnnp-2013-305340

Deep brain stimulation for tremor resulting from acquired brain injury

H A Sitsapesan, P Holland, Z Oliphant, N De Pennington, J-S Brittain, N Jenkinson, C Joint, T Z Aziz, A L Green

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Abstract

OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).

METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.

RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.

CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

Original language	English
Pages (from-to)	811-5
Number of pages	5
Journal	Journal of Neurology Neurosurgery and Psychiatry
Volume	85
Issue number	7
DOIs	https://doi.org/10.1136/jnnp-2013-305340
Publication status	Published - Jul 2014

Bibliographical note

Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

Keywords

Adult
Aged
Brain Injuries
Deep Brain Stimulation
Electrodes, Implanted
Female
Humans
Male
Severity of Illness Index
Single-Blind Method
Treatment Outcome
Tremor
Young Adult

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10.1136/jnnp-2013-305340

Sitsapesan_et_al_Deep_Brain_Stimulation_Journal_Neurology_Neurosurgery_Psychiatry_2014_Post-Print
This is the Author Accepted Manuscript Version of the article published in final form at: http://dx.doi.org/10.1136/jnnp-2013-305340. Checked July 2015
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Cite this

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title = "Deep brain stimulation for tremor resulting from acquired brain injury",

abstract = "OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.",

keywords = "Adult, Aged, Brain Injuries, Deep Brain Stimulation, Electrodes, Implanted, Female, Humans, Male, Severity of Illness Index, Single-Blind Method, Treatment Outcome, Tremor, Young Adult",

author = "Sitsapesan, {H A} and P Holland and Z Oliphant and {De Pennington}, N and J-S Brittain and N Jenkinson and C Joint and Aziz, {T Z} and Green, {A L}",

note = "Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.",

year = "2014",

month = jul,

doi = "10.1136/jnnp-2013-305340",

language = "English",

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T1 - Deep brain stimulation for tremor resulting from acquired brain injury

AU - Sitsapesan, H A

AU - Holland, P

AU - Oliphant, Z

AU - De Pennington, N

AU - Brittain, J-S

AU - Jenkinson, N

AU - Joint, C

AU - Aziz, T Z

AU - Green, A L

N1 - Published by the BMJ Publishing Group Limited. For permission to use (where not already granted under a licence) please go to http://group.bmj.com/group/rights-licensing/permissions.

PY - 2014/7

Y1 - 2014/7

N2 - OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

AB - OBJECTIVES: To evaluate the efficacy of deep brain stimulation (DBS) in the treatment of tremor resulting from acquired brain injury (ABI).METHODS: A series of eight consecutive patients with post-ABI tremor were treated with DBS of the ventro-oralis posterior (VOP)/zona incerta (ZI) region, and subsequently underwent blinded assessments using Bain's tremor severity scale.RESULTS: VOP/ZI DBS produced a mean reduction in tremor severity of 80.75% based on Bain's tremor severity scale, with significant reductions in all five component tremor subscores: rest, postural, kinetic, proximal and distal. No adverse neurological complications were reported, although one patient experienced exacerbation of pre-existing gait ataxia.CONCLUSION: VOP/ZI stimulation is demonstrated here to be an effective and safe approach for the treatment of post-ABI tremor in the largest series published at the time of writing.

KW - Adult

KW - Aged

KW - Brain Injuries

KW - Deep Brain Stimulation

KW - Electrodes, Implanted

KW - Female

KW - Humans

KW - Male

KW - Severity of Illness Index

KW - Single-Blind Method

KW - Treatment Outcome

KW - Tremor

KW - Young Adult

U2 - 10.1136/jnnp-2013-305340

DO - 10.1136/jnnp-2013-305340

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C2 - 24306513

SN - 0022-3050

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SP - 811

EP - 815

JO - Journal of Neurology Neurosurgery and Psychiatry

JF - Journal of Neurology Neurosurgery and Psychiatry

IS - 7

ER -

Deep brain stimulation for tremor resulting from acquired brain injury

Abstract

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Keywords

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