Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

F Jessen; W Block; F Traber; E Keller; S Flacke; R Lamerichs; HH Schild; Reinhard Heun

Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

F Jessen
, W Block
, F Traber
, E Keller
, S Flacke
, R Lamerichs
, HH Schild
, Reinhard Heun

Research output: Contribution to journal › Article

76 Citations (Scopus)

Abstract

In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.

Original language	English
Pages (from-to)	930-932
Number of pages	3
Journal	Neurology
Volume	57
Publication status	Published - 1 Jan 2001

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title = "Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients",

abstract = "In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.",

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year = "2001",

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pages = "930--932",

journal = "Neurology",

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T1 - Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

AU - Jessen, F

AU - Block, W

AU - Traber, F

AU - Keller, E

AU - Flacke, S

AU - Lamerichs, R

AU - Schild, HH

AU - Heun, Reinhard

PY - 2001/1/1

Y1 - 2001/1/1

N2 - In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.

AB - In this (1)H-MRS follow-up study of the medial temporal lobe (MTL) in patients with AD, the authors report a correlation of N-acetylaspartate (NAA)/creatine (Cr) with cognitive decline. Severely progressed patients showed a reduction, whereas stable or mildly progressed subjects showed a slight increase of NAA/Cr. The reduction of NAA/Cr in the MTL represents a correlate of cognitive deterioration in AD, whereas it is of limited use to detect subtle changes over time in clinically stable patients.

M3 - Article

C2 - 11552037

VL - 57

SP - 930

EP - 932

JO - Neurology

JF - Neurology

ER -

Decrease of N-acetylaspartate in the MTL correlates with cognitive decline of AD patients

Abstract

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