Decorin treatment of spinal cord injury

Maryam Esmaeili, Martin Berry, Ann Logan, Zubair Ahmed

Research output: Contribution to journalArticlepeer-review

22 Citations (Scopus)


The scarring response after a penetrant central nervous system injury results from the interaction between invading leptominingeal/pericyte-derived fibroblasts and endogenous reactive astrocytes about the wound margin. Extracellular matrix and scar-derived axon growth inhibitory molecules fill the lesion site providing both a physical and chemical barrier to regenerating axons. Decorin, a small leucine-rich chondroitin-dermatan sulphate proteoglycan expressed by neurons and astrocytes in the central nervous system, is both anti-fibrotic and anti-inflammatory and attenuates the formation and partial dissolution of established and chronic scars. Here, we discuss the potential of using Decorin to antagonise scarring in the central nervous system.

Original languageEnglish
Pages (from-to)1653-6
Number of pages4
JournalNeural Regeneration Research
Issue number18
Publication statusPublished - 15 Sept 2014


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