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A new peptide sequence (MB1) has been designed which, in the presence of a trivalent lanthanide ion, has been programmed to self-assemble to form a three stranded metallo-coiled coil, Ln(III)(MB1)3. The binding site has been incorporated into the hydrophobic core using natural amino acids, restricting water access to the lanthanide. The resulting terbium coiled coil displays luminescent properties consistent with a lack of first coordination sphere water molecules. Despite this the gadolinium coiled coil, the first to be reported, displays promising magnetic resonance contrast capabilities.
|Journal||Journal of the American Chemical Society|
|Early online date||9 Jan 2014|
|Publication status||Published - 29 Jan 2014|
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- 1 Finished
Luminescent nanoparticles as trackers for imaging of flows and sensing phenomena in microchannels
Engineering & Physical Science Research Council
18/05/09 → 17/01/13
Project: Research Councils