Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Stephen Taylor; AN Jayasuriya; A Berry; G Gilleran; NE Dufty; L Else; DJ Back; EJ Smit

doi:10.1097/QAD.0b013e32833ead18

Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Stephen Taylor
, AN Jayasuriya
, A Berry
, G Gilleran
, NE Dufty
, L Else
, DJ Back
, EJ Smit

Immunology and Immunotherapy

Research output: Contribution to journal › Article

12 Citations (Scopus)

Abstract

Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

Original language	English
Pages (from-to)	2583-7
Number of pages	5
Journal	Aids
Volume	24
Issue number	16
DOIs	https://doi.org/10.1097/QAD.0b013e32833ead18
Publication status	Published - 23 Oct 2010

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

SDG 3 Good Health and Well-being

Access to Document

10.1097/QAD.0b013e32833ead18

Cite this

@article{7d0b2be58826462c9667e96920551c61,

title = "Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.",

abstract = "Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20\% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.",

author = "Stephen Taylor and AN Jayasuriya and A Berry and G Gilleran and NE Dufty and L Else and DJ Back and EJ Smit",

year = "2010",

month = oct,

day = "23",

doi = "10.1097/QAD.0b013e32833ead18",

language = "English",

volume = "24",

pages = "2583--7",

journal = "Aids",

publisher = "Lippincott Williams and Wilkins",

number = "16",

}

TY - JOUR

T1 - Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

AU - Taylor, Stephen

AU - Jayasuriya, AN

AU - Berry, A

AU - Gilleran, G

AU - Dufty, NE

AU - Else, L

AU - Back, DJ

AU - Smit, EJ

PY - 2010/10/23

Y1 - 2010/10/23

N2 - Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

AB - Variable antiretroviral drug penetration into the genital tract may contribute to the differential evolution of HIV-1 and the emergence of drug resistance. We compared concentrations of darunavir in 34 time-matched blood plasma and seminal plasma samples from 18 HIV-1 positive men. Darunavir in seminal plasma were approximately 10-20% of that achieved in blood at matched time points postdrug ingestion. All seminal plasma darunavir were above the protein-corrected EC₅₀ values for wild-type HIV-1.

U2 - 10.1097/QAD.0b013e32833ead18

DO - 10.1097/QAD.0b013e32833ead18

M3 - Article

C2 - 20736813

VL - 24

SP - 2583

EP - 2587

JO - Aids

JF - Aids

IS - 16

ER -

Darunavir concentrations exceed the protein-corrected EC₅₀ for wild-type HIV in the semen of HIV-1-infected men.

Abstract

UN SDGs

Access to Document

Fingerprint

Cite this