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Abstract
Despite available technology and the knowledge that chemical pollution damages human and ecosystem health, chemical pollution remains rampant, ineffectively monitored, rarely prevented, and only occasionally mitigated. We present a framework that helps address current major challenges in the monitoring and assessment of chemical pollution by broadening the use of the sentinel species Daphnia as a diagnostic agent of water pollution. And where prevention has failed, we propose the application of Daphnia as a bioremediation agent to help reduce hazards from chemical mixtures in the environment. By applying "omics" technologies to Daphnia exposed to real-world ambient chemical mixtures, we show improvements at detecting bioactive components of chemical mixtures, determining the potential effects of untested chemicals within mixtures, and identifying targets of toxicity. We also show that using Daphnia strains that naturally adapted to chemical pollution as removal agents of ambient chemical mixtures can sustainably improve environmental health protection. Expanding the use of Daphnia beyond its current applications in regulatory toxicology has the potential to improve both the assessment and the remediation of environmental pollution.
Original language | English |
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Pages (from-to) | 14237-14248 |
Number of pages | 12 |
Journal | Environmental Science and Technology |
Volume | 56 |
Issue number | 20 |
Early online date | 28 Sept 2022 |
DOIs | |
Publication status | Published - 18 Oct 2022 |
Bibliographical note
Funding Information:This work is part of the China–U.K. Research of Safeguarding Natural Water project, funded by the Royal Society International Collaboration Award (Grant No. IC160121), and was performed as part of the ASPIS Cluster. This project receives funding from the European Union’s Horizon 2020 Research and Innovation program under Grant Agreement No. 965406 (PrecisionTox). The project is also supported by the Alan Turing Institute (under EPSRC Grant R-BIR-001). M.A. is supported by a fellowship of the Petroleum Technology Development Fund, Nigeria (PTDF/ED/OSS/POF/1369/18). We thank Chantal Jackson for the artwork of and the TOC and William Scavone for the artwork of . The arsenic data supporting the bioremediation case study were generated by the FENAC facility at the University of Birmingham. The PFOS and atrazine data supporting the bioremediation case study were generated by the GEES Mass Spectrometry Facility at the University of Birmingham.
Keywords
- bioremediation
- chemical mixtures
- monitoring
- omics
- water flea
- water pollution
ASJC Scopus subject areas
- General Chemistry
- Environmental Chemistry
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PrecisionTox: New Approach Methodologies for Chemical Safety
Viant, M. (Researcher), Lee, R. (Co-Investigator), Roberts, R. (Researcher), Orsini, L. (Co-Investigator), Müller, F. (Co-Investigator), Zhou, J. (Co-Investigator), Colbourne, J. (Principal Investigator), Weber, R. (Co-Investigator) & Cavoski, A. (Co-Investigator)
1/02/21 → 31/07/26
Project: EU
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GCRF - China-UK Research for Safeguarding Natural Waters
Colbourne, J. (Principal Investigator)
1/12/16 → 31/05/23
Project: Research Councils