Dantrolene and the effect of temperature on the spontaneous release of transmitter at the frog neuromuscular junction

S J Publicover, C J Duncan

Research output: Contribution to journalArticlepeer-review

4 Citations (Scopus)

Abstract

The characteristic effect of temperature on m.e.p.p. frequency at the amphibian neuromuscular junction is unaltered by the presence of Dantrolene (an agent that is believed to reduce the efflux of Ca2+ from intracellular stores) or by changes in [Ca2+)o. It is concluded that temperature affects the release system directly, with a transition temperature at about 16 degrees C.

Original languageEnglish
Pages (from-to)859-60
Number of pages2
JournalExperientia
Volume37
Issue number8
Publication statusPublished - 1981

Keywords

  • Animals
  • Calcium
  • Dantrolene
  • Membrane Potentials
  • Neuromuscular Junction
  • Neurotransmitter Agents
  • Rana pipiens
  • Temperature

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