Abstract
RAD18 functions to promote DNA damage tolerance (DTT), a process that ensures faithful genome duplication. Protein ubiquitylation/deubiquitylation is a critical regulatory mechanism controlling DTT. Recently, we have identified the deubiquitylating enzyme USP7 as a component of the DTT machinery that acts to protect RAD18 from proteasome-dependent degradation.
| Original language | English |
|---|---|
| Article number | e1063571 |
| Journal | Molecular and Cellular Oncology |
| Volume | 3 |
| Issue number | 1 |
| DOIs | |
| Publication status | Published - 2 Jan 2016 |
Bibliographical note
Publisher Copyright:© 2016, © 2016 Taylor & Francis Group, LLC.
UN SDGs
This output contributes to the following UN Sustainable Development Goals (SDGs)
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SDG 3 Good Health and Well-being
ASJC Scopus subject areas
- Molecular Medicine
- Cancer Research
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