Dairy intake and Parkinson's disease: a mendelian randomization study

Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium; Cloé Domenighetti; Pierre-Emmanuel Sugier; Ashwin Ashok Kumar Sreelatha; Claudia Schulte; Sandeep Grover; Océane Mohamed; Berta Portugal; Patrick May; Dheeraj R Bobbili; Milena Radivojkov-Blagojevic; Peter Lichtner; Andrew B Singleton; Dena G Hernandez; Connor Edsall; George D Mellick; Alexander Zimprich; Walter Pirker; Ekaterina Rogaeva; Anthony E Lang; Sulev Koks; Pille Taba; Suzanne Lesage; Alexis Brice; Jean-Christophe Corvol; Marie-Christine Chartier-Harlin; Eugénie Mutez; Kathrin Brockmann; Angela B Deutschländer; Georges M Hadjigeorgiou; Efthimos Dardiotis; Leonidas Stefanis; Athina Maria Simitsi; Enza Maria Valente; Simona Petrucci; Stefano Duga; Letizia Straniero; Anna Zecchinelli; Gianni Pezzoli; Laura Brighina; Carlo Ferrarese; Grazia Annesi; Andrea Quattrone; Monica Gagliardi; Hirotaka Matsuo; Yusuke Kawamura; Nobutaka Hattori; Kenya Nishioka; Sun Ju Chung; Yun Joong Kim; Carl E Clarke

doi:10.1002/mds.28902

Dairy intake and Parkinson's disease: a mendelian randomization study

Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium, Cloé Domenighetti, Pierre-Emmanuel Sugier, Ashwin Ashok Kumar Sreelatha, Claudia Schulte, Sandeep Grover, Océane Mohamed, Berta Portugal, Patrick May, Dheeraj R Bobbili, Milena Radivojkov-Blagojevic, Peter Lichtner, Andrew B Singleton, Dena G Hernandez, Connor Edsall, George D Mellick, Alexander Zimprich, Walter Pirker, Ekaterina Rogaeva, Anthony E LangSulev Koks, Pille Taba, Suzanne Lesage, Alexis Brice, Jean-Christophe Corvol, Marie-Christine Chartier-Harlin, Eugénie Mutez, Kathrin Brockmann, Angela B Deutschländer, Georges M Hadjigeorgiou, Efthimos Dardiotis, Leonidas Stefanis, Athina Maria Simitsi, Enza Maria Valente, Simona Petrucci, Stefano Duga, Letizia Straniero, Anna Zecchinelli, Gianni Pezzoli, Laura Brighina, Carlo Ferrarese, Grazia Annesi, Andrea Quattrone, Monica Gagliardi, Hirotaka Matsuo, Yusuke Kawamura, Nobutaka Hattori, Kenya Nishioka, Sun Ju Chung, Yun Joong Kim, Carl E Clarke

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

Abstract

Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.

Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).

Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).

Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029).

Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.

Original language	English
Pages (from-to)	857-864
Journal	Movement Disorders
Volume	37
Issue number	4
Early online date	8 Jan 2022
DOIs	https://doi.org/10.1002/mds.28902
Publication status	E-pub ahead of print - 8 Jan 2022

Keywords

dairy intake; Parkinson's disease; Mendelian randomization

ASJC Scopus subject areas

Neurology
Clinical Neurology

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Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium, Domenighetti, C., Sugier, P.-E., Ashok Kumar Sreelatha, A., Schulte, C., Grover, S., Mohamed, O., Portugal, B., May, P., Bobbili, D. R., Radivojkov-Blagojevic, M., Lichtner, P., Singleton, A. B., Hernandez, D. G., Edsall, C., Mellick, G. D., Zimprich, A., Pirker, W., Rogaeva, E., ... Clarke, C. E. (2022). Dairy intake and Parkinson's disease: a mendelian randomization study. Movement Disorders, 37(4), 857-864. Advance online publication. https://doi.org/10.1002/mds.28902

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abstract = "Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029).Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.",

keywords = "dairy intake; Parkinson's disease; Mendelian randomization",

author = "{Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium} and Clo{\'e} Domenighetti and Pierre-Emmanuel Sugier and {Ashok Kumar Sreelatha}, Ashwin and Claudia Schulte and Sandeep Grover and Oc{\'e}ane Mohamed and Berta Portugal and Patrick May and Bobbili, {Dheeraj R} and Milena Radivojkov-Blagojevic and Peter Lichtner and Singleton, {Andrew B} and Hernandez, {Dena G} and Connor Edsall and Mellick, {George D} and Alexander Zimprich and Walter Pirker and Ekaterina Rogaeva and Lang, {Anthony E} and Sulev Koks and Pille Taba and Suzanne Lesage and Alexis Brice and Jean-Christophe Corvol and Marie-Christine Chartier-Harlin and Eug{\'e}nie Mutez and Kathrin Brockmann and Deutschl{\"a}nder, {Angela B} and Hadjigeorgiou, {Georges M} and Efthimos Dardiotis and Leonidas Stefanis and Simitsi, {Athina Maria} and Valente, {Enza Maria} and Simona Petrucci and Stefano Duga and Letizia Straniero and Anna Zecchinelli and Gianni Pezzoli and Laura Brighina and Carlo Ferrarese and Grazia Annesi and Andrea Quattrone and Monica Gagliardi and Hirotaka Matsuo and Yusuke Kawamura and Nobutaka Hattori and Kenya Nishioka and Chung, {Sun Ju} and Kim, {Yun Joong} and Clarke, {Carl E}",

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pages = "857--864",

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Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium, Domenighetti, C, Sugier, P-E, Ashok Kumar Sreelatha, A, Schulte, C, Grover, S, Mohamed, O, Portugal, B, May, P, Bobbili, DR, Radivojkov-Blagojevic, M, Lichtner, P, Singleton, AB, Hernandez, DG, Edsall, C, Mellick, GD, Zimprich, A, Pirker, W, Rogaeva, E, Lang, AE, Koks, S, Taba, P, Lesage, S, Brice, A, Corvol, J-C, Chartier-Harlin, M-C, Mutez, E, Brockmann, K, Deutschländer, AB, Hadjigeorgiou, GM, Dardiotis, E, Stefanis, L, Simitsi, AM, Valente, EM, Petrucci, S, Duga, S, Straniero, L, Zecchinelli, A, Pezzoli, G, Brighina, L, Ferrarese, C, Annesi, G, Quattrone, A, Gagliardi, M, Matsuo, H, Kawamura, Y, Hattori, N, Nishioka, K, Chung, SJ, Kim, YJ & Clarke, CE 2022, 'Dairy intake and Parkinson's disease: a mendelian randomization study', Movement Disorders, vol. 37, no. 4, pp. 857-864. https://doi.org/10.1002/mds.28902

Dairy intake and Parkinson's disease: a mendelian randomization study. / Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium; Domenighetti, Cloé; Sugier, Pierre-Emmanuel et al.
In: Movement Disorders, Vol. 37, No. 4, 08.01.2022, p. 857-864.

Research output: Contribution to journal › Article › peer-review

TY - JOUR

T1 - Dairy intake and Parkinson's disease

T2 - a mendelian randomization study

AU - Comprehensive Unbiased Risk Factor Assessment for Genetics and Environment in Parkinson's Disease (Courage-PD) Consortium

AU - Domenighetti, Cloé

AU - Sugier, Pierre-Emmanuel

AU - Ashok Kumar Sreelatha, Ashwin

AU - Schulte, Claudia

AU - Grover, Sandeep

AU - Mohamed, Océane

AU - Portugal, Berta

AU - May, Patrick

AU - Bobbili, Dheeraj R

AU - Radivojkov-Blagojevic, Milena

AU - Lichtner, Peter

AU - Singleton, Andrew B

AU - Hernandez, Dena G

AU - Edsall, Connor

AU - Mellick, George D

AU - Zimprich, Alexander

AU - Pirker, Walter

AU - Rogaeva, Ekaterina

AU - Lang, Anthony E

AU - Koks, Sulev

AU - Taba, Pille

AU - Lesage, Suzanne

AU - Brice, Alexis

AU - Corvol, Jean-Christophe

AU - Chartier-Harlin, Marie-Christine

AU - Mutez, Eugénie

AU - Brockmann, Kathrin

AU - Deutschländer, Angela B

AU - Hadjigeorgiou, Georges M

AU - Dardiotis, Efthimos

AU - Stefanis, Leonidas

AU - Simitsi, Athina Maria

AU - Valente, Enza Maria

AU - Petrucci, Simona

AU - Duga, Stefano

AU - Straniero, Letizia

AU - Zecchinelli, Anna

AU - Pezzoli, Gianni

AU - Brighina, Laura

AU - Ferrarese, Carlo

AU - Annesi, Grazia

AU - Quattrone, Andrea

AU - Gagliardi, Monica

AU - Matsuo, Hirotaka

AU - Kawamura, Yusuke

AU - Hattori, Nobutaka

AU - Nishioka, Kenya

AU - Chung, Sun Ju

AU - Kim, Yun Joong

AU - Clarke, Carl E

PY - 2022/1/8

Y1 - 2022/1/8

N2 - Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029).Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.

AB - Background: Previous prospective studies highlighted dairy intake as a risk factor for Parkinson's disease (PD), particularly in men. It is unclear whether this association is causal or explained by reverse causation or confounding.Objective: The aim is to examine the association between genetically predicted dairy intake and PD using two-sample Mendelian randomization (MR).Methods: We genotyped a well-established instrumental variable for dairy intake located in the lactase gene (rs4988235) within the Courage-PD consortium (23 studies; 9823 patients and 8376 controls of European ancestry).Results: Based on a dominant model, there was an association between genetic predisposition toward higher dairy intake and PD (odds ratio [OR] per one serving per day = 1.70, 95% confidence interval = 1.12–2.60, P = 0.013) that was restricted to men (OR = 2.50 [1.37–4.56], P = 0.003; P-difference with women = 0.029).Conclusions: Using MR, our findings provide further support for a causal relationship between dairy intake and higher PD risk, not biased by confounding or reverse causation. Further studies are needed to elucidate the underlying mechanisms.

KW - dairy intake; Parkinson's disease; Mendelian randomization

UR - http://www.scopus.com/inward/record.url?scp=85128406510&partnerID=8YFLogxK

U2 - 10.1002/mds.28902

DO - 10.1002/mds.28902

M3 - Article

C2 - 34997937

SN - 0885-3185

VL - 37

SP - 857

EP - 864

JO - Movement Disorders

JF - Movement Disorders

IS - 4

ER -

Dairy intake and Parkinson's disease: a mendelian randomization study

Abstract

Keywords

ASJC Scopus subject areas

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