Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells

Wenxi He, Yaqing Zhang, Jing Zhang, Qing Yu, Ping Wang, Zhihua Wang, Anthony J Smith

Research output: Contribution to journalArticlepeer-review

16 Citations (Scopus)

Abstract

Odontoblasts are involved in innate immunity against invading microorganisms. However, the mechanisms of host inflammatory responses to bacterial DNA in odontoblasts are not fully understood. The purpose of this study was to investigate whether microbial cytidine-phosphate-guanosine (CpG) DNA influences interleukin-8 (IL-8) expression in odontoblasts and the signaling pathways involved.
Original languageEnglish
Pages (from-to)780-5
Number of pages6
JournalJournal of Endodontics
Volume38
Issue number6
DOIs
Publication statusPublished - 2012

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