Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells

Wenxi He; Yaqing Zhang; Jing Zhang; Qing Yu; Ping Wang; Zhihua Wang; Anthony J Smith

doi:10.1016/j.joen.2012.02.026

Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells

Wenxi He, Yaqing Zhang, Jing Zhang, Qing Yu, Ping Wang, Zhihua Wang, Anthony J Smith

Dentistry

Research output: Contribution to journal › Article › peer-review

16 Citations (Scopus)

Abstract

Odontoblasts are involved in innate immunity against invading microorganisms. However, the mechanisms of host inflammatory responses to bacterial DNA in odontoblasts are not fully understood. The purpose of this study was to investigate whether microbial cytidine-phosphate-guanosine (CpG) DNA influences interleukin-8 (IL-8) expression in odontoblasts and the signaling pathways involved.

Original language	English
Pages (from-to)	780-5
Number of pages	6
Journal	Journal of Endodontics
Volume	38
Issue number	6
DOIs	https://doi.org/10.1016/j.joen.2012.02.026
Publication status	Published - 2012

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10.1016/j.joen.2012.02.026

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title = "Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells",

abstract = "Odontoblasts are involved in innate immunity against invading microorganisms. However, the mechanisms of host inflammatory responses to bacterial DNA in odontoblasts are not fully understood. The purpose of this study was to investigate whether microbial cytidine-phosphate-guanosine (CpG) DNA influences interleukin-8 (IL-8) expression in odontoblasts and the signaling pathways involved.",

author = "Wenxi He and Yaqing Zhang and Jing Zhang and Qing Yu and Ping Wang and Zhihua Wang and Smith, {Anthony J}",

year = "2012",

doi = "10.1016/j.joen.2012.02.026",

language = "English",

volume = "38",

pages = "780--5",

journal = "Journal of Endodontics",

issn = "0099-2399",

publisher = "Elsevier",

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TY - JOUR

T1 - Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells

AU - He, Wenxi

AU - Zhang, Yaqing

AU - Zhang, Jing

AU - Yu, Qing

AU - Wang, Ping

AU - Wang, Zhihua

AU - Smith, Anthony J

PY - 2012

Y1 - 2012

N2 - Odontoblasts are involved in innate immunity against invading microorganisms. However, the mechanisms of host inflammatory responses to bacterial DNA in odontoblasts are not fully understood. The purpose of this study was to investigate whether microbial cytidine-phosphate-guanosine (CpG) DNA influences interleukin-8 (IL-8) expression in odontoblasts and the signaling pathways involved.

AB - Odontoblasts are involved in innate immunity against invading microorganisms. However, the mechanisms of host inflammatory responses to bacterial DNA in odontoblasts are not fully understood. The purpose of this study was to investigate whether microbial cytidine-phosphate-guanosine (CpG) DNA influences interleukin-8 (IL-8) expression in odontoblasts and the signaling pathways involved.

U2 - 10.1016/j.joen.2012.02.026

DO - 10.1016/j.joen.2012.02.026

M3 - Article

C2 - 22595112

VL - 38

SP - 780

EP - 785

JO - Journal of Endodontics

JF - Journal of Endodontics

SN - 0099-2399

IS - 6

ER -

Cytidine-phosphate-guanosine oligonucleotides induce interleukin-8 production through activation of TLR9, MyD88, NF-κB, and ERK pathways in odontoblast cells

Abstract

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