Cysteine dioxygenase: modulation of expression in human cell lines by cytokines with control of sulphate formation

[No Value] [No Value]; Rosemary Waring

doi:10.1016/S0887-2333(02)00031-0

Cysteine dioxygenase: modulation of expression in human cell lines by cytokines with control of sulphate formation

[No Value] [No Value], Rosemary Waring

Biosciences

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Abstract

Cysteine dioxygenase (CDO) is the initial and rate-limiting enzyme involved in the oxidative degradation of cysteine to inorganic sulphate. It is believed to be the major source of sulphate in vivo. Inflammatory conditions such as rheumatoid arthritis have been linked with high plasma cysteine:sulphate ratios in patients. The cytokines tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) have been shown to inhibit the expression of CDO in neuronal (TE671) and hepatic (Chang) human cell lines at nanomolar concentrations. Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents. (C) 2002 Published by Elsevier Science Ltd.

Original language	English
Pages (from-to)	481-483
Number of pages	3
Journal	Toxicology in Vitro
Volume	16
Issue number	4
DOIs	https://doi.org/10.1016/S0887-2333(02)00031-0
Publication status	Published - 1 Aug 2002

Keywords

cytokine
human cell lines
cysteine dioxygenase
TNF-alpha
sulfate

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10.1016/S0887-2333(02)00031-0

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title = "Cysteine dioxygenase: modulation of expression in human cell lines by cytokines with control of sulphate formation",

abstract = "Cysteine dioxygenase (CDO) is the initial and rate-limiting enzyme involved in the oxidative degradation of cysteine to inorganic sulphate. It is believed to be the major source of sulphate in vivo. Inflammatory conditions such as rheumatoid arthritis have been linked with high plasma cysteine:sulphate ratios in patients. The cytokines tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) have been shown to inhibit the expression of CDO in neuronal (TE671) and hepatic (Chang) human cell lines at nanomolar concentrations. Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents. (C) 2002 Published by Elsevier Science Ltd.",

keywords = "cytokine, human cell lines, cysteine dioxygenase, TNF-alpha, sulfate",

author = "{[No Value]}, {[No Value]} and Rosemary Waring",

year = "2002",

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doi = "10.1016/S0887-2333(02)00031-0",

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T1 - Cysteine dioxygenase: modulation of expression in human cell lines by cytokines with control of sulphate formation

AU - [No Value], [No Value]

AU - Waring, Rosemary

PY - 2002/8/1

Y1 - 2002/8/1

N2 - Cysteine dioxygenase (CDO) is the initial and rate-limiting enzyme involved in the oxidative degradation of cysteine to inorganic sulphate. It is believed to be the major source of sulphate in vivo. Inflammatory conditions such as rheumatoid arthritis have been linked with high plasma cysteine:sulphate ratios in patients. The cytokines tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) have been shown to inhibit the expression of CDO in neuronal (TE671) and hepatic (Chang) human cell lines at nanomolar concentrations. Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents. (C) 2002 Published by Elsevier Science Ltd.

AB - Cysteine dioxygenase (CDO) is the initial and rate-limiting enzyme involved in the oxidative degradation of cysteine to inorganic sulphate. It is believed to be the major source of sulphate in vivo. Inflammatory conditions such as rheumatoid arthritis have been linked with high plasma cysteine:sulphate ratios in patients. The cytokines tumour necrosis factor-alpha (TNF-alpha) and transforming growth factor-beta (TGF-beta) have been shown to inhibit the expression of CDO in neuronal (TE671) and hepatic (Chang) human cell lines at nanomolar concentrations. Cytokine release may therefore modulate sulphate production and hence regulate formation of sulphated biocomponents. (C) 2002 Published by Elsevier Science Ltd.

KW - cytokine

KW - human cell lines

KW - cysteine dioxygenase

KW - TNF-alpha

KW - sulfate

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U2 - 10.1016/S0887-2333(02)00031-0

DO - 10.1016/S0887-2333(02)00031-0

M3 - Article

SN - 1879-3177

VL - 16

SP - 481

EP - 483

JO - Toxicology in Vitro

JF - Toxicology in Vitro

IS - 4

ER -

Cysteine dioxygenase: modulation of expression in human cell lines by cytokines with control of sulphate formation

Abstract

Keywords

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