CYP1A- and CYP3A- immunopositive protein levels in digestive gland of mussel (mytilus galloprovincialis) from the Mediterranean Sea

Jennifer Shaw, LD Peters, James Chipman

Research output: Contribution to journalArticle

16 Citations (Scopus)

Abstract

CYP1A-immunopositive protein can be elevated in response to planar PAHs and PCBs in Mytilus sp. digestive gland whilst CYP3A-immunopositive protein has been associated with testosterone 6beta-hydroxylation in fish. Levels of CYP1A- and CYP3A-immunopositive protein were determined in Mytilus galloprovincialis digestive gland microsomes collected from 12 sites in the Mediterranean Sea during May and September 2001. CYP1A-immunopositive protein was significantly highest at contaminated sites whilst CYP3A-immunopositive protein was significantly lowest. A weak negative correlation (r(2) = 0.21) was seen between CYP1A- and CYP3A-immunopositive protein. Little evidence of differences at the different sampling times was observed. These results confirm previous work indicating elevation of CYP1A-immunopositive protein in Mytilus sp. digestive gland at contaminated sites. Further study is required to characterise CYP3A-like expression in Mytilus and to elucidate the consequences of possible CYP3A-like down-regulation at contaminated sites. (C) 2004 Elsevier Ltd. All rights reserved.
Original languageEnglish
Pages (from-to)649-653
Number of pages5
JournalMarine Environmental Research
Volume58
DOIs
Publication statusPublished - 1 Jan 2004

Keywords

  • mixed function oxidase
  • Mediterranean
  • Mytilus
  • sublethal effects
  • reproduction

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