TY - JOUR
T1 - Cycle threshold values are inversely associated with poorer outcomes in hospitalized patients with COVID-19
T2 - a prospective, observational cohort study conducted at a UK tertiary hospital
AU - Wright, Jenny
AU - Achana, Felix
AU - Diwakar, Lavanya
AU - Semple, Malcolm G.
AU - Carroll, Will D.
AU - Baillie, Kenneth
AU - Thompson, Christopher
AU - Alcock, Alice
AU - Kemp, Timothy S.
N1 - Publisher Copyright:
© 2021 The Authors
PY - 2021/10
Y1 - 2021/10
N2 - This single-centre observational study demonstrated that lower cycle threshold (Ct) values (indicating higher viral loads) on admission to hospital were associated with poorer outcomes in unvaccinated, hospitalized patients with coronavirus disease 2019 (COVID-19). Demographic and outcome data were collected prospectively for all adult patients who tested positive for severe acute respiratory syndrome coronavirus-2 on admission to the University Hospitals North Midlands NHS Trust between 1 February and 1 July 2020. Nasopharyngeal swab samples were obtained, and a valid Ct value was determined for all patients using the Viasure reverse transcription polymerase chain reaction assay, validated by Public Health England, on admission to hospital. Multi-variable logistic regression results based on data from 618 individuals demonstrated a significant inverse relationship between the odds of death and Ct values (adjusted odds ratio 0.95, 95% confidence interval 0.92–0.98, P=0.001).
AB - This single-centre observational study demonstrated that lower cycle threshold (Ct) values (indicating higher viral loads) on admission to hospital were associated with poorer outcomes in unvaccinated, hospitalized patients with coronavirus disease 2019 (COVID-19). Demographic and outcome data were collected prospectively for all adult patients who tested positive for severe acute respiratory syndrome coronavirus-2 on admission to the University Hospitals North Midlands NHS Trust between 1 February and 1 July 2020. Nasopharyngeal swab samples were obtained, and a valid Ct value was determined for all patients using the Viasure reverse transcription polymerase chain reaction assay, validated by Public Health England, on admission to hospital. Multi-variable logistic regression results based on data from 618 individuals demonstrated a significant inverse relationship between the odds of death and Ct values (adjusted odds ratio 0.95, 95% confidence interval 0.92–0.98, P=0.001).
KW - COVID-19
KW - Respiratory infection
KW - Viral infection
UR - http://www.scopus.com/inward/record.url?scp=85115410727&partnerID=8YFLogxK
U2 - 10.1016/j.ijid.2021.08.022
DO - 10.1016/j.ijid.2021.08.022
M3 - Article
C2 - 34403784
AN - SCOPUS:85115410727
SN - 1201-9712
VL - 111
SP - 333
EP - 335
JO - International Journal of Infectious Diseases
JF - International Journal of Infectious Diseases
ER -
