Cutting Edge: NF-kappaB2 is a negative regulator of dendritic cell function

K Speirs, L Lieberman, Jorge Caamano, CA Hunter, P Scott

Research output: Contribution to journalArticle

43 Citations (Scopus)


RelB, a member of the NF-kappaB family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-kappaB2/p100. The studies presented in this report show that DCs lacking NF-kappaB2 have dramatically enhanced RelB activity, associated with increased MHC class II and costimulatory molecule expression and an enhanced ability to induce CD4(+) T cell responses. These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses.
Original languageEnglish
Pages (from-to)752-756
Number of pages5
JournalJournal of Immunology
Issue number2
Publication statusPublished - 1 Jan 2004


Dive into the research topics of 'Cutting Edge: NF-kappaB2 is a negative regulator of dendritic cell function'. Together they form a unique fingerprint.

Cite this