Abstract
RelB, a member of the NF-kappaB family of transcription factors, is essential for dendritic cell (DC) maturation. Recent findings indicate that RelB is exclusively regulated through its interaction with cytoplasmic NF-kappaB2/p100. The studies presented in this report show that DCs lacking NF-kappaB2 have dramatically enhanced RelB activity, associated with increased MHC class II and costimulatory molecule expression and an enhanced ability to induce CD4(+) T cell responses. These studies identify a novel role for NF-kappaB2 in the negative regulation of RelB-induced DC maturation, with critical consequences for the regulation of adaptive immune responses.
Original language | English |
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Pages (from-to) | 752-756 |
Number of pages | 5 |
Journal | Journal of Immunology |
Volume | 172 |
Issue number | 2 |
Publication status | Published - 1 Jan 2004 |