Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy

Andre van van Maurik; Manuela Herber; Kathryn J Wood; Nick D Jones

Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy

Andre van van Maurik, Manuela Herber, Kathryn J Wood, Nick D Jones

Immunology and Immunotherapy

Research output: Contribution to journal › Article › peer-review

150 Citations (Scopus)

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Abstract

Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.

Original language	English
Pages (from-to)	5401-4
Number of pages	4
Journal	Journal of Immunology
Volume	169
Issue number	10
Publication status	Published - 15 Nov 2002

Keywords

Injections, Intraperitoneal
Animals
Antigens, CD40
Heart Transplantation
Skin Transplantation
Mice
Receptors, Interleukin-2
Mice, Transgenic
Mice, Inbred BALB C
CD4-Positive T-Lymphocytes
Mice, Knockout
CD40 Ligand
Antibodies, Monoclonal
Epitopes, T-Lymphocyte
Mice, Inbred CBA
Mice, Inbred NZB
Adoptive Transfer
Graft Rejection
Antigens, CD4
CD8-Positive T-Lymphocytes
Mice, Inbred C57BL
T-Lymphocyte Subsets

Cite this

@article{292f39ffba9047c696fbc543ad91aa5f,

title = "Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy",

abstract = "Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.",

keywords = "Injections, Intraperitoneal, Animals, Antigens, CD40, Heart Transplantation, Skin Transplantation, Mice, Receptors, Interleukin-2, Mice, Transgenic, Mice, Inbred BALB C, CD4-Positive T-Lymphocytes, Mice, Knockout, CD40 Ligand, Antibodies, Monoclonal, Epitopes, T-Lymphocyte, Mice, Inbred CBA, Mice, Inbred NZB, Adoptive Transfer, Graft Rejection, Antigens, CD4, CD8-Positive T-Lymphocytes, Mice, Inbred C57BL, T-Lymphocyte Subsets",

author = "{van Maurik}, {Andre van} and Manuela Herber and Wood, {Kathryn J} and Jones, {Nick D}",

year = "2002",

month = nov,

day = "15",

language = "English",

volume = "169",

pages = "5401--4",

journal = "Journal of Immunology",

issn = "0022-1767",

publisher = "American Association of Immunologists",

number = "10",

}

TY - JOUR

T1 - Cutting edge

T2 - CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy

AU - van Maurik, Andre van

AU - Herber, Manuela

AU - Wood, Kathryn J

AU - Jones, Nick D

PY - 2002/11/15

Y1 - 2002/11/15

N2 - Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.

AB - Blockade of CD40-CD154 interactions can facilitate long-term allograft acceptance in selected rodent and in primate models, but, due to the ability of CD154-independent CD8(+) T cells to initiate graft rejection, this strategy is not always effective. In this work we demonstrate that blockade of the CD40-CD154 pathway at the time of transplantation enables the generation of donor alloantigen-specific CD4(+)CD25(+) regulatory T cells, and that if the regulatory cells are present in sufficient numbers they can suppress allograft rejection mediated by CD154-independent CD8(+) T cells.

KW - Injections, Intraperitoneal

KW - Animals

KW - Antigens, CD40

KW - Heart Transplantation

KW - Skin Transplantation

KW - Mice

KW - Receptors, Interleukin-2

KW - Mice, Transgenic

KW - Mice, Inbred BALB C

KW - CD4-Positive T-Lymphocytes

KW - Mice, Knockout

KW - CD40 Ligand

KW - Antibodies, Monoclonal

KW - Epitopes, T-Lymphocyte

KW - Mice, Inbred CBA

KW - Mice, Inbred NZB

KW - Adoptive Transfer

KW - Graft Rejection

KW - Antigens, CD4

KW - CD8-Positive T-Lymphocytes

KW - Mice, Inbred C57BL

KW - T-Lymphocyte Subsets

M3 - Article

C2 - 12421913

SN - 0022-1767

VL - 169

SP - 5401

EP - 5404

JO - Journal of Immunology

JF - Journal of Immunology

IS - 10

ER -

Cutting edge: CD4+CD25+ alloantigen-specific immunoregulatory cells that can prevent CD8+ T cell-mediated graft rejection: implications for anti-CD154 immunotherapy

Abstract

Keywords

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