Cushing's syndrome in women with polycystic ovaries and hyperandrogenism

PG Fegan, DD Sandeman, Nils Krone, D Bosman, PJ Wood, Paul Stewart, NA Hanley

Research output: Contribution to journalArticle

8 Citations (Scopus)


Background A 41-year-old woman presented to an endocrinology-gynecology clinic having been diagnosed 7 years earlier with polycystic ovarian syndrome on account of hirsutism, subfertility, greasy skin, acne and multiple ovarian cysts. Ovulation induction had led to a successful pregnancy. Subfertility recurred, however, and persisted alongside a new diagnosis of hypertension and progressive weight gain. Upon examination, the patient was hypertensive with facial plethora, rounded facies and violaceous abdominal striae. Investigations Low-dose dexamethasone test, bedtime salivary and 24-h urinary free cortisol estimations, CT scan of the abdomen, and serum hormone and gonadotropin analyses. Diagnosis Cushing's syndrome due to a right adrenocortical adenoma. Management The patient underwent laparoscopic right adrenalectomy, which led to resolution of all symptoms, signs and biochemical abnormalities.
Original languageEnglish
Pages (from-to)778-783
Number of pages6
JournalNature clinical practice. Endocrinology & metabolism
Issue number11
Publication statusPublished - 1 Nov 2007


  • polycystic ovarian syndrome
  • cortisol
  • Cushing's syndrome


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