Current therapeutic strategies in non-alcoholic fatty liver disease.

Joanna Dowman, Matthew Armstrong, Jeremy Tomlinson, Philip Newsome

Research output: Contribution to journalArticle

92 Citations (Scopus)


Background: Non-alcoholic fatty liver disease (NAFLD) encompasses a spectrum of disease ranging from simple steatosis through steatohepatitis (NASH) to increasing fibrosis and eventual cirrhosis. NAFLD is the hepatic manifestation of the metabolic syndrome, and has now become the most common cause of liver disease in Western countries, with the more advanced stages of disease being associated with an increased risk of liver-related morbidity and mortality. The optimal management of patients with NAFLD remains a clinical challenge. Aim: To describe established and emerging strategies for the treatment of NAFLD. Methods: Relevant research and review articles were identified by searching PubMed. Selected articles referenced in these publications were also examined. Results: Good quality randomised-controlled studies have demonstrated the need for multi-facetted lifestyle interventions in patients with NAFLD including the need for diet, exercise and behavioural counselling. Despite several trials of pharmacological agents no highly effective treatment yet exists, with surgery representing the mainstay for advanced disease. Conclusions: A multidisciplinary approach, with a major focus on lifestyle change, represents best treatment pending the development of new therapeutic options.
Original languageEnglish
JournalDiabetes, Obesity and Metabolism
Publication statusPublished - 30 Mar 2011


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