Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies

Saiju Jacob; Yusuf A Rajabally

doi:10.2174/157015909790031166

Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies

Saiju Jacob, Yusuf A Rajabally

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

Intravenous immunoglobulins (IVIg) have been shown in a number of trials, to be an effective treatment for the three main types of inflammatory neuropathies: Guillain-Barré Syndrome (GBS), chronic inflammatory demyelinating polyneuropathy (CIDP), and multifocal motor neuropathy (MMN). IVIg is thought to exert its immunomodulatory effects by affecting several components of the immune system including B-cells, T-cells, macrophages, complement, cytokines and cellular adhesion molecules. This article reviews the published evidence and the principal postulated mechanisms of action of intravenous immunoglobulins with special emphasis on inflammatory neuropathies.

Original language	English
Pages (from-to)	337-42
Number of pages	6
Journal	Current Neuropharmacology
Volume	7
Issue number	4
DOIs	https://doi.org/10.2174/157015909790031166
Publication status	Published - Dec 2009

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Current proposed mechanisms of action of intravenous immunoglobulins in inflammatory neuropathies

Abstract

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