Crystallization-induced gelling as a method to 3D print low water content non-isocyanate polyurethane hydrogels

Noe Fanjul-Mosteirin, Robert Aguirresarobe, Naroa Sadaba, Aitor Larrañaga, Edurne Marin, Jaime Martin, Nicolas Ramos-Gomez, Maria Chiara Arno, Haritz Sardon, Andrew Dove

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The use of three-dimensional (3D) printable hydrogels for biomedical applications has attracted considerable attention as a consequence of the ability to precisely define the morphology of the printed object, allowing patients’ needs to be targeted. However, the majority of hydrogels do not possess suitable mechanical properties to fulfill an adequate rheological profile for printability, and hence, 3D printing of cross-linked networks is challenging and normally requires postprinting modifications to obtain the desired scaffolds. In this work, we took advantage of the crystallization process of poly(ethylene glycol) to print non-isocyanate poly(hydroxyurethane) hydrogels with tunable mechanical properties. As a consequence of the crystallization process, the hydrogel modulus can be tuned up to 3 orders of magnitude upon heating up to 40 °C, offering an interesting strategy to directly 3D-print hydrogels without the need of postprinting cross-linking. Moreover, the absence of any toxicity makes these materials ideal candidates for biomedical applications.
Original languageEnglish
Pages (from-to)7194-7202
JournalChemistry of Materials
Issue number18
Early online date14 Sept 2021
Publication statusE-pub ahead of print - 14 Sept 2021


  • bioprinting
  • cytocompatible
  • hydrogels


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