Crosstalk between glucocorticoids and mitogen-activated protein kinase signalling pathways

Andrew R. Clark*, Marina Lasa

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

94 Citations (Scopus)


Synthetic glucocorticoids are potent modulators of the immune system, and are clinically invaluable in the treatment of a wide variety of conditions. However, their use can be limited by harmful side effects, and their mechanisms of action remain poorly understood and controversial. It has recently been reported that glucocorticoids induce the expression of two genes that participate in cross-talk with the mitogen-activated protein kinase signalling pathways. It is possible that both therapeutic and harmful effects of glucocorticoids may be mediated by these genes.

Original languageEnglish
Pages (from-to)404-411
Number of pages8
JournalCurrent Opinion in Pharmacology
Issue number4
Publication statusPublished - 1 Aug 2003

ASJC Scopus subject areas

  • Pharmacology
  • Drug Discovery


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