TY - JOUR
T1 - Cross-Sectional Area of the Tibial Nerve in Diabetic Peripheral Neuropathy Patients
T2 - A Systematic Review and Meta-Analysis of Ultrasonography Studies
AU - Senarai, Thanyaporn
AU - Pratipanawatr, Thongchai
AU - Yurasakpong, Laphatrada
AU - Kruepunga, Nutmethee
AU - Limwachiranon, Jarukitt
AU - Phanthong, Phetcharat
AU - Meemon, Krai
AU - Yammine, Kaissar
AU - Suwannakhan, Athikhun
N1 - Copyright:
© 2022 by the authors.
PY - 2022/11/22
Y1 - 2022/11/22
N2 - Background: There is a link between diabetic peripheral neuropathy (DPN) progression and the increase in the cross-sectional area (CSA) of the tibial nerve at the ankle. Nevertheless, no prior meta-analysis has been conducted to evaluate its usefulness for the diagnosis of DPN.
Methods: We searched Google Scholar, Scopus, and PubMed for potential studies. Studies had to report tibial nerve CSA at the ankle and diabetes status (DM, DPN, or healthy) to be included. A random-effect meta-analysis was applied to calculate pooled tibial nerve CSA and mean differences across the groups. Subgroup and correlational analyses were conducted to study the potential covariates.
Results: The analysis of 3295 subjects revealed that tibial nerve CSA was 13.39 mm2 (CI: 10.94–15.85) in DM patients and 15.12 mm2 (CI: 11.76–18.48) in DPN patients. The CSA was 1.93 mm2 (CI: 0.92–2.95, I2 = 98.69%, p < 0.01) larger than DPN-free diabetic patients. The diagnostic criteria of DPN and age were also identified as potential moderators of tibial nerve CSA.
Conclusions: Although tibial nerve CSA at the ankle was significantly larger in the DPN patients, its clinical usefulness is limited by the overlap between groups and the inconsistency in the criteria used to diagnose DPN.
AB - Background: There is a link between diabetic peripheral neuropathy (DPN) progression and the increase in the cross-sectional area (CSA) of the tibial nerve at the ankle. Nevertheless, no prior meta-analysis has been conducted to evaluate its usefulness for the diagnosis of DPN.
Methods: We searched Google Scholar, Scopus, and PubMed for potential studies. Studies had to report tibial nerve CSA at the ankle and diabetes status (DM, DPN, or healthy) to be included. A random-effect meta-analysis was applied to calculate pooled tibial nerve CSA and mean differences across the groups. Subgroup and correlational analyses were conducted to study the potential covariates.
Results: The analysis of 3295 subjects revealed that tibial nerve CSA was 13.39 mm2 (CI: 10.94–15.85) in DM patients and 15.12 mm2 (CI: 11.76–18.48) in DPN patients. The CSA was 1.93 mm2 (CI: 0.92–2.95, I2 = 98.69%, p < 0.01) larger than DPN-free diabetic patients. The diagnostic criteria of DPN and age were also identified as potential moderators of tibial nerve CSA.
Conclusions: Although tibial nerve CSA at the ankle was significantly larger in the DPN patients, its clinical usefulness is limited by the overlap between groups and the inconsistency in the criteria used to diagnose DPN.
KW - cross-sectional area
KW - diabetes
KW - meta-analysis
KW - peripheral neuropathy
KW - tibial nerve
KW - ultrasound
UR - https://www.scopus.com/pages/publications/85144513326
U2 - 10.3390/medicina58121696
DO - 10.3390/medicina58121696
M3 - Review article
C2 - 36556898
AN - SCOPUS:85144513326
SN - 1010-660X
VL - 58
JO - Medicina (Lithuania)
JF - Medicina (Lithuania)
IS - 12
M1 - 1696
ER -
