COVID-19: Seroprevalence and vaccine responses in UK dental care professionals

Adrian Shields, Sian Faustini, Caroline Kristunas, Alex Cook, Claire Backhouse, Lynz Dunbar, Daniel Ebanks, Beena Emmanuel, Eddie Crouch, Annika Kroeger, Josefine Hirschfeld, Praveen Sharma, Raza Jaffery, Sylwia Nowak, Samantha Gee, Mark Drayson, Alex Richter, Thomas Dietrich, Iain Chapple

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Dental care professionals (DCPs) are thought to be at enhanced risk of occupational exposure to severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). However, robust data to support this from large-scale seroepidemiological studies are lacking. We report a longitudinal seroprevalence analysis of antibodies to SARS-CoV-2 spike glycoprotein, with baseline sampling prior to large-scale practice reopening in July 2020 and follow-up postimplementation of new public health guidance on infection prevention control (IPC) and enhanced personal protective equipment (PPE). In total, 1,507 West Midlands DCPs were recruited into this study in June 2020. Baseline seroprevalence was determined using a combined IgGAM enzyme-linked immunosorbent assay and the cohort followed longitudinally for 6 mo until January/February 2021 through the second wave of the coronavirus disease 2019 pandemic in the United Kingdom and vaccination commencement. Baseline seroprevalence was 16.3%, compared to estimates in the regional population of 6% to 7%. Seropositivity was retained in over 70% of participants at 3- and 6-mo follow-up and conferred a 75% reduced risk of infection. Nonwhite ethnicity and living in areas of greater deprivation were associated with increased baseline seroprevalence. During follow-up, no polymerase chain reaction–proven infections occurred in individuals with a baseline anti–SARS-CoV-2 IgG level greater than 147.6 IU/ml with respect to the World Health Organization international standard 20-136. After vaccination, antibody responses were more rapid and of higher magnitude in those individuals who were seropositive at baseline. Natural infection with SARS-CoV-2 prior to enhanced PPE was significantly higher in DCPs than the regional population. Natural infection leads to a serological response that remains detectable in over 70% of individuals 6 mo after initial sampling and 9 mo from the peak of the first wave of the pandemic. This response is associated with protection from future infection. Even if serological responses wane, a single dose of the Pfizer-BioNTech 162b vaccine is associated with an antibody response indicative of immunological memory.

Original languageEnglish
Pages (from-to)1220-1227
Number of pages8
JournalJournal of Dental Research
Issue number11
Early online date2 Jun 2021
Publication statusPublished - Oct 2021

Bibliographical note

The authors disclosed receipt of the following financial support for the research, authorship, and/or publication of this article: The authors are grateful for funding from the Association of Clinical Biochemistry and Laboratory Medicine for supporting this work.


  • dentistry
  • SARS-CoV-2
  • vaccination
  • antibodies
  • seroepidemiological studies
  • occupational exposure


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