COVID-19 in haematology patients: a multicentre West Midlands clinical outcomes analysis on behalf of West Midlands Research Consortium

Hana Morrissey, Patrick Ball, Anandadeep Mandal, Alan Nevil, Shankara Paneesha, Supratik Basu, Farheen Karim, Md Imran Hossain, Neil Phillips, Jahanzeb Khawaja, Jackie Stone, Duncan Murray, Katie Randall, Vidhya Murthy, Bhuvan Kishore, Manos Nikolousis, Guy Pratt, Jeff Neilson, Nick Pemberton, Farooq Wandroo

Research output: Contribution to journalLetterpeer-review

1 Citation (Scopus)
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Abstract

The authors report on a detailed insight into 112 patients with comorbidity of haematological conditions and coronavirus disease 2019 (COVID-19), admitted into nine National Health Services Trusts in the West Midlands Area of the United Kingdom, between 1st of March 2020 and 31st May 2020. In the study cohort, 82% of patients had a malignant haematological disorder whist 18% had a non-malignant haematological condition. Increasing age, breathlessness, reduction in oxygen saturation under 90% and abnormal chest x-ray were independently associated with higher mortality. Other long-term co-morbidities had no identified adverse impact in this population. Survival analysis demonstrated that the COVID-19 severity score had a significant adverse correlation on patient outcome. COVID-19 patients classified as low risk, based on their primary haematological condition, showed significantly shorter survival time than those in the high-risk category, which may be due to shielding strategy. The 55% overall mortality in this cohort suggests that patients with haematological conditions had higher mortality rate.
Original languageEnglish
JournalBritish Journal of Haematology
Early online date5 Nov 2020
DOIs
Publication statusE-pub ahead of print - 5 Nov 2020

Bibliographical note

My contribution: Data Scientist, Research design and write-up of the analysis.

Collaboration: Multidisciplinary Work with NHS, West Midlands Research Consortium.

About the Journal: The British Journal of Haematology is a peer-reviewed medical journal focusing on hematology and other blood-related topics. It's impact factor is 5.518 (2019, latest)

Keywords

  • COVID-19
  • Haematology patients
  • Coronavirus Pandemic
  • COVID-19 Survival Analysis
  • Severity of COVID-19 Symptoms

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