Abstract
The SARS-CoV-2 virus is known to mediate attack via ACE-2 Receptor, thus having adverse effects on cardiovascular, respiratory, digestive and reproductive systems, the latter being an area of emerging concern, due to the associated impact on fertility, with potential for an outsized effect on population distribution and socioeconomic road map in subsequent years. This narrative review aims to put forth the current evidence of effect of SARS-CoV-2 on human fertility from a multipronged immunologic, haematologic, and gynaecologic perspective; highlighting the areas of contradiction and potential future measures. A literature search was conducted through the MEDLINE and SCOPUS databases to identify articles on the subject in English. Relevant information was extracted from around 300 articles for this review. The existing data give non-conclusive evidence about the impact of SARS-CoV-2 infection on fertility; however, a greater impact on male fertility as compared to females merits further exploration. However, reproduction and fertility is a key concern and considering the pandemic is prolonged, natural conception or ART require extra precautions.
| Original language | English |
|---|---|
| Pages (from-to) | 1885-1894 |
| Number of pages | 10 |
| Journal | Rheumatology International |
| Volume | 41 |
| Issue number | 11 |
| Early online date | 28 Aug 2021 |
| DOIs | |
| Publication status | Published - Nov 2021 |
Bibliographical note
Publisher Copyright:© 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature.
Keywords
- Autoimmunity
- COVID-19
- Female fertility
- Male fertility
- Sexual/vertical transmission
ASJC Scopus subject areas
- Rheumatology
- Immunology and Allergy
- Immunology